USP9X (ubiquitin specific peptidase 9 X-linked)

2009-09-01  

Identity

HGNC
USP9X
LOCATION
Xp11.4
LOCUSID
8239
ALIAS
DFFRX,FAF,FAM,MRX99,MRXS99F
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8239
MIM: 300072
HGNC: 12632
Ensembl: ENSG00000124486

Variants:

dbSNP: 8239
ClinVar: 8239
TCGA: ENSG00000124486
COSMIC: USP9X

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124486ENST00000324545Q93008
ENSG00000124486ENST00000378308Q93008

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Amyloid fiber formationREACTOMER-HSA-977225
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
Downregulation of SMAD2/3:SMAD4 transcriptional activityREACTOMER-HSA-2173795
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363309542023Ablation of EWS-FLI1 by USP9X inhibition suppresses cancer cell growth in Ewing sarcoma.3
365253742023USP9X promotes lipopolysaccharide-stimulated acute lung injury by deubiquitination of NLRP3.3
369950922023KSHV Viral Protein Kinase Interacts with USP9X to Modulate the Viral Lifecycle.1
370302952023USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities.1
372601832023Deubiquitinase USP9X loss sensitizes renal cancer cells to mTOR inhibition.2
373142162023USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle.0
374547382023Deubiquitinase USP9X stabilizes RNA m(6)A demethylase ALKBH5 and promotes acute myeloid leukemia cell survival.2
363309542023Ablation of EWS-FLI1 by USP9X inhibition suppresses cancer cell growth in Ewing sarcoma.3
365253742023USP9X promotes lipopolysaccharide-stimulated acute lung injury by deubiquitination of NLRP3.3
369950922023KSHV Viral Protein Kinase Interacts with USP9X to Modulate the Viral Lifecycle.1
370302952023USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities.1
372601832023Deubiquitinase USP9X loss sensitizes renal cancer cells to mTOR inhibition.2
373142162023USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle.0
374547382023Deubiquitinase USP9X stabilizes RNA m(6)A demethylase ALKBH5 and promotes acute myeloid leukemia cell survival.2
346066822022DDX3 interacts with USP9X and participates in deubiquitination of the anti-apoptotic protein MCL1.3

Citation

Dessen P

USP9X (ubiquitin specific peptidase 9 X-linked)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51119/js/lib/css/tumors-explorer/