PIAS2 (protein inhibitor of activated STAT 2)

2009-09-01  

Identity

HGNC
PIAS2
LOCATION
18q21.1
LOCUSID
9063
ALIAS
ARIP3,DIP,MIZ1,PIASX,SIZ2,ZMIZ4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9063
MIM: 603567
HGNC: 17311
Ensembl: ENSG00000078043

Variants:

dbSNP: 9063
ClinVar: 9063
TCGA: ENSG00000078043
COSMIC: PIAS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078043ENST00000324794O75928
ENSG00000078043ENST00000398654A0A0A0MS92
ENSG00000078043ENST00000545673B4DGW0
ENSG00000078043ENST00000585916O75928
ENSG00000078043ENST00000586953K7ER97
ENSG00000078043ENST00000587810K7EQX5
ENSG00000078043ENST00000589917K7EJT4
ENSG00000078043ENST00000592212A0A087WUY7
ENSG00000078043ENST00000592221K7EMP6

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Jak-STAT signaling pathwayKEGGko04630
Small cell lung cancerKEGGko05222
Ubiquitin mediated proteolysisKEGGhsa04120
Jak-STAT signaling pathwayKEGGhsa04630
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Developmental BiologyREACTOMER-HSA-1266738
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387448182024dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe.1
387448182024dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe.1
362514112022Integrative transcriptome analysis reveals TEKT2 and PIAS2 involvement in diabetic nephropathy.2
362514112022Integrative transcriptome analysis reveals TEKT2 and PIAS2 involvement in diabetic nephropathy.2
337638412021Expression of PIAS Genes in Migraine Patients.1
342342812021PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia.18
337638412021Expression of PIAS Genes in Migraine Patients.1
342342812021PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia.18
322492122020SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation.11
322492122020SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation.11
307839052019p38 MAPK pathway-dependent SUMOylation of Elk-1 and phosphorylation of PIAS2 correlate with the downregulation of Elk-1 activity in heat-stressed HeLa cells.4
308616112019PIAS genes as disease markers in bipolar disorder.3
310842432019The investigation of relevancy between PIAS1 and PIAS2 gene expression and disease severity of multiple sclerosis.2
315827152019Single Nucleotide Polymorphisms of Ubiquitin-Related Genes were Associated with Allograft Fibrosis of Renal Transplant Fibrosis.2
307839052019p38 MAPK pathway-dependent SUMOylation of Elk-1 and phosphorylation of PIAS2 correlate with the downregulation of Elk-1 activity in heat-stressed HeLa cells.4

Citation

Dessen P

PIAS2 (protein inhibitor of activated STAT 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51129/js/lib/img/tumors-explorer/