PARD6A (par-6 family cell polarity regulator alpha)

2009-11-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
PAR-6A,PAR6,PAR6C,PAR6alpha,TAX40,TIP-40
FUSION GENES

Other Information

Locus ID:

NCBI: 50855
MIM: 607484
HGNC: 15943
Ensembl: ENSG00000102981

Variants:

dbSNP: 50855
ClinVar: 50855
TCGA: ENSG00000102981
COSMIC: PARD6A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102981ENST00000219255Q9NPB6
ENSG00000102981ENST00000458121Q9NPB6
ENSG00000102981ENST00000602551R4GMM2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Tight junctionKEGGko04530
Axon guidanceKEGGhsa04360
Tight junctionKEGGhsa04530
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)REACTOMER-HSA-2173791
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
Asymmetric localization of PCP proteinsREACTOMER-HSA-4608870
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
389548052024FOXN2, identified as a novel biomarker in serum, modulates the transforming growth factor-beta signaling pathway through its interaction with partitioning defective 6 homolog alpha, contributing to the pathogenesis of gastric cancer.0
389548052024FOXN2, identified as a novel biomarker in serum, modulates the transforming growth factor-beta signaling pathway through its interaction with partitioning defective 6 homolog alpha, contributing to the pathogenesis of gastric cancer.0
365421942023Par6 Enhances Glioma Invasion by Activating MEK/ERK Pathway Through a LIN28/let-7d Positive Feedback Loop.2
365421942023Par6 Enhances Glioma Invasion by Activating MEK/ERK Pathway Through a LIN28/let-7d Positive Feedback Loop.2
353797752022Partitioning defective 6 homolog alpha (PARD6A) promotes epithelial-mesenchymal transition via integrin β1-ILK-SNAIL1 pathway in ovarian cancer.7
353797752022Partitioning defective 6 homolog alpha (PARD6A) promotes epithelial-mesenchymal transition via integrin β1-ILK-SNAIL1 pathway in ovarian cancer.7
319146152020Par6 regulates cell cycle progression through enhancement of Akt/PI3K/GSK-3β signaling pathway activation in glioma.6
325802092020A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity.18
319146152020Par6 regulates cell cycle progression through enhancement of Akt/PI3K/GSK-3β signaling pathway activation in glioma.6
325802092020A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity.18
296963442018PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization.16
299924882018AhR activation protects intestinal epithelial barrier function through regulation of Par-6.8
304081222018A Tuba/Cdc42/Par6A complex is required to ensure singularity in apical domain formation during enterocyte polarization.4
296963442018PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization.16
299924882018AhR activation protects intestinal epithelial barrier function through regulation of Par-6.8

Citation

Dessen P

PARD6A (par-6 family cell polarity regulator alpha)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51178/js/lib/teaching-explorer/