CDK19 (cyclin dependent kinase 19)

2010-01-01  

Identity

HGNC
CDK19
LOCATION
6q21
LOCUSID
23097
ALIAS
CDC2L6,CDK11,DEE87,EIEE87,bA346C16.3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23097
MIM: 614720
HGNC: 19338
Ensembl: ENSG00000155111

Variants:

dbSNP: 23097
ClinVar: 23097
TCGA: ENSG00000155111
COSMIC: CDK19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155111ENST00000323817Q9BWU1
ENSG00000155111ENST00000368911Q9BWU1
ENSG00000155111ENST00000413605F6QTA4
ENSG00000155111ENST00000457688Q5JQZ9
ENSG00000155111ENST00000463016H0YDW9

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373784332023CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.7
373784332023CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.7
351107262022CDK19 regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells by suppressing p53-mediated transcription of p21.6
351813332022Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.5
354516512022Hotair promotes the migration and proliferation in ovarian cancer by miR-222-3p/CDK19 axis.5
360066972022CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.3
351107262022CDK19 regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells by suppressing p53-mediated transcription of p21.6
351813332022Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.5
354516512022Hotair promotes the migration and proliferation in ovarian cancer by miR-222-3p/CDK19 axis.5
360066972022CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.3
334955292021CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants.9
335684212021A novel variant of CDK19 causes a severe neurodevelopmental disorder with infantile spasms.1
346495202021Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma.1
334955292021CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants.9
335684212021A novel variant of CDK19 causes a severe neurodevelopmental disorder with infantile spasms.1

Citation

Dessen P

CDK19 (cyclin dependent kinase 19)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51315/gene-fusions-explorer/gene-fusions/haematological-explorer/