TICRR (TOPBP1 interacting checkpoint and replication regulator)

2010-03-01  

Identity

HGNC
TICRR
LOCATION
15q26.1
LOCUSID
90381
ALIAS
C15orf42,SLD3,Treslin
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 90381
MIM: 613298
HGNC: 28704
Ensembl: ENSG00000140534

Variants:

dbSNP: 90381
ClinVar: 90381
TCGA: ENSG00000140534
COSMIC: TICRR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140534ENST00000268138Q7Z2Z1
ENSG00000140534ENST00000560985Q7Z2Z1
ENSG00000140534ENST00000561095H0YN97

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
350914222022Refining the domain architecture model of the replication origin firing factor Treslin/TICRR.5
355957542022Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer.8
363117532022Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm.0
350914222022Refining the domain architecture model of the replication origin firing factor Treslin/TICRR.5
355957542022Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer.8
363117532022Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm.0
334954132021Overexpression of TICRR and PPIF confer poor prognosis in endometrial cancer identified by gene co-expression network analysis.11
345343482021The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase.9
334954132021Overexpression of TICRR and PPIF confer poor prognosis in endometrial cancer identified by gene co-expression network analysis.11
345343482021The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase.9
329667912020Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication.12
329667912020Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication.12
300379032018Interaction between DUE-B and Treslin is required to load Cdc45 on chromatin in human cells.1
300379032018Interaction between DUE-B and Treslin is required to load Cdc45 on chromatin in human cells.1
284390152017Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.25

Citation

Dessen P

TICRR (TOPBP1 interacting checkpoint and replication regulator)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51393/gene-fusions/css/case-report-explorer/