E2F8 (E2F transcription factor 8)

2010-03-01  

Identity

HGNC
E2F8
LOCATION
11p15.1
LOCUSID
79733
ALIAS
E2F-8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79733
MIM: 612047
HGNC: 24727
Ensembl: ENSG00000129173

Variants:

dbSNP: 79733
ClinVar: 79733
TCGA: ENSG00000129173
COSMIC: E2F8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129173ENST00000250024A0AVK6
ENSG00000129173ENST00000527884A0AVK6
ENSG00000129173ENST00000532666E9PMT9
ENSG00000129173ENST00000620009A0AVK6

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
thymus
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386610622024ENO1 promotes trophoblast invasion regulated by E2F8 in recurrent miscarriage.1
387958252024TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta.0
386610622024ENO1 promotes trophoblast invasion regulated by E2F8 in recurrent miscarriage.1
387958252024TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta.0
376354862023E2F8 knockdown suppresses cell proliferation and induces cell cycle arrest via Wnt/β-Catenin pathway in ovarian cancer.0
378633242023E2F8 exerts cancer-promoting effects by transcriptionally activating RRM2 and E2F8 knockdown synergizes with WEE1 inhibition in suppressing lung adenocarcinoma.1
378887712023Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner.1
376354862023E2F8 knockdown suppresses cell proliferation and induces cell cycle arrest via Wnt/β-Catenin pathway in ovarian cancer.0
378633242023E2F8 exerts cancer-promoting effects by transcriptionally activating RRM2 and E2F8 knockdown synergizes with WEE1 inhibition in suppressing lung adenocarcinoma.1
378887712023Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner.1
362416252022Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.5
362416252022Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.5
317331232020RNA-binding protein NONO promotes breast cancer proliferation by post-transcriptional regulation of SKP2 and E2F8.47
319297592020E2F8 regulates the proliferation and invasion through epithelial-mesenchymal transition in cervical cancer.14
319900342020Carcinogenesis effects of E2F transcription factor 8 (E2F8) in hepatocellular carcinoma outcomes: an integrated bioinformatic report.4

Citation

Dessen P

E2F8 (E2F transcription factor 8)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51400/js/deep-insight-explorer/favicon/manifest.json