PHF20 (PHD finger protein 20)

2010-04-01  

Identity

HGNC
PHF20
LOCATION
20q11.22
LOCUSID
51230
ALIAS
C20orf104,GLEA2,HCA58,NZF,TDRD20A,TZP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51230
MIM: 610335
HGNC: 16098
Ensembl: ENSG00000025293

Variants:

dbSNP: 51230
ClinVar: 51230
TCGA: ENSG00000025293
COSMIC: PHF20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000025293ENST00000339089Q5JWZ0
ENSG00000025293ENST00000374000Q5JXL1
ENSG00000025293ENST00000374012Q9BVI0
ENSG00000025293ENST00000420233B0QZ19
ENSG00000025293ENST00000449988B0QYY0
ENSG00000025293ENST00000452270F8WCQ1

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through Association with Co-factorsREACTOMER-HSA-6804759

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
359796282022N6-methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation.9
359796282022N6-methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation.9
339827732021PHF20 inhibition promotes apoptosis and cisplatin chemosensitivity via the OCT4‑p‑STAT3‑MCL1 signaling pathway in hypopharyngeal squamous cell carcinoma.4
339827732021PHF20 inhibition promotes apoptosis and cisplatin chemosensitivity via the OCT4‑p‑STAT3‑MCL1 signaling pathway in hypopharyngeal squamous cell carcinoma.4
294524182018PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4.14
294524182018PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4.14
269605732016G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.34
277603182016PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.28
269605732016G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.34
277603182016PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.28
267224042015Expression of PHF20 protein contributes to good prognosis of NSCLC and is associated with Bax expression.0
267224042015Expression of PHF20 protein contributes to good prognosis of NSCLC and is associated with Bax expression.0
246751052014Altered expression of tumor suppressor PHF20 in myeloproliferative neoplasms.1
246751052014Altered expression of tumor suppressor PHF20 in myeloproliferative neoplasms.1
229756852013PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.16

Citation

Dessen P

PHF20 (PHD finger protein 20)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51408/css/cancer-prone-explorer/gene-fusions/?id=51408