PHF20 (PHD finger protein 20)

2010-04-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
C20orf104,GLEA2,HCA58,NZF,TDRD20A,TZP
FUSION GENES

Other Information

Locus ID:

NCBI: 51230
MIM: 610335
HGNC: 16098
Ensembl: ENSG00000025293

Variants:

dbSNP: 51230
ClinVar: 51230
TCGA: ENSG00000025293
COSMIC: PHF20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000025293ENST00000339089Q5JWZ0
ENSG00000025293ENST00000374000Q5JXL1
ENSG00000025293ENST00000374012Q9BVI0
ENSG00000025293ENST00000420233B0QZ19
ENSG00000025293ENST00000449988B0QYY0
ENSG00000025293ENST00000452270F8WCQ1

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through Association with Co-factorsREACTOMER-HSA-6804759

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
359796282022N6-methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation.9
359796282022N6-methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation.9
339827732021PHF20 inhibition promotes apoptosis and cisplatin chemosensitivity via the OCT4‑p‑STAT3‑MCL1 signaling pathway in hypopharyngeal squamous cell carcinoma.4
339827732021PHF20 inhibition promotes apoptosis and cisplatin chemosensitivity via the OCT4‑p‑STAT3‑MCL1 signaling pathway in hypopharyngeal squamous cell carcinoma.4
294524182018PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4.14
294524182018PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4.14
269605732016G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.34
277603182016PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.28
269605732016G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.34
277603182016PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.28
267224042015Expression of PHF20 protein contributes to good prognosis of NSCLC and is associated with Bax expression.0
267224042015Expression of PHF20 protein contributes to good prognosis of NSCLC and is associated with Bax expression.0
246751052014Altered expression of tumor suppressor PHF20 in myeloproliferative neoplasms.1
246751052014Altered expression of tumor suppressor PHF20 in myeloproliferative neoplasms.1
229756852013PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.16

Citation

Dessen P

PHF20 (PHD finger protein 20)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51408/js/img/gene-fusions-explorer/