LIN28A (lin-28 homolog A)

2010-04-01  

Identity

HGNC
LIN28A
LOCATION
1p36.11
LOCUSID
79727
ALIAS
CSDD1,LIN-28,LIN28,ZCCHC1,lin-28A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79727
MIM: 611043
HGNC: 15986
Ensembl: ENSG00000131914

Variants:

dbSNP: 79727
ClinVar: 79727
TCGA: ENSG00000131914
COSMIC: LIN28A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131914ENST00000254231Q9H9Z2
ENSG00000131914ENST00000326279Q9H9Z2

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of pluripotent stem cellsREACTOMER-HSA-452723

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381679132024Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells.0
382169642024Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28.2
384300332024Circular RNA circ_0096041 promotes osteosarcoma cell proliferation and migration via sponging miR-556-5p and regulating LIN28A expression.2
386123952024Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway.0
386362522024GNAI3 mediated by Lin28A regulates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal stem cells by mediating the NF-κB/NLRP3 inflammasome pathway.1
387293262024Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury.0
381679132024Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells.0
382169642024Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28.2
384300332024Circular RNA circ_0096041 promotes osteosarcoma cell proliferation and migration via sponging miR-556-5p and regulating LIN28A expression.2
386123952024Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway.0
386362522024GNAI3 mediated by Lin28A regulates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal stem cells by mediating the NF-κB/NLRP3 inflammasome pathway.1
387293262024Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury.0
364367982023Lin28a induced mitochondrial dysfunction in human granulosa cells via suppressing LARS2 expression.5
366493082023LIN28 expression and function in medulloblastoma.2
366583472023Analysis of LIN28A variants in patients with Parkinson's disease.0

Citation

Dessen P

LIN28A (lin-28 homolog A)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51415/gene-fusions/gene-fusions-explorer/hgnc