TRMT2A (tRNA methyltransferase 2 homolog A)

2010-07-01  

Identity

HGNC
TRMT2A
LOCATION
22q11.21
LOCUSID
27037
ALIAS
HTF9C
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27037
MIM: 611151
HGNC: 24974
Ensembl: ENSG00000099899

Variants:

dbSNP: 27037
ClinVar: 27037
TCGA: ENSG00000099899
COSMIC: TRMT2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099899ENST00000252136Q8IZ69
ENSG00000099899ENST00000403707Q8IZ69
ENSG00000099899ENST00000404751Q8IZ69
ENSG00000099899ENST00000439169F2Z2W7
ENSG00000099899ENST00000444256H7BZZ4
ENSG00000099899ENST00000444845H7C100
ENSG00000099899ENST00000445045C9K041

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373954482023Human TRMT2A methylates tRNA and contributes to translation fidelity.5
373954482023Human TRMT2A methylates tRNA and contributes to translation fidelity.5
337993312021m(5)U54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAs.23
337993312021m(5)U54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAs.23
305020852019TRMT2A is a novel cell cycle regulator that suppresses cell proliferation.17
313618982019FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA.31
305020852019TRMT2A is a novel cell cycle regulator that suppresses cell proliferation.17
313618982019FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA.31
203073202010The expression of TRMT2A, a novel cell cycle regulated protein, identifies a subset of breast cancer patients with HER2 over-expression that are at an increased risk of recurrence.19
203073202010The expression of TRMT2A, a novel cell cycle regulated protein, identifies a subset of breast cancer patients with HER2 over-expression that are at an increased risk of recurrence.19
180754732007HTF9C gene of 22q11.21 region associates with schizophrenia having deficit-sustained attention.3
180754732007HTF9C gene of 22q11.21 region associates with schizophrenia having deficit-sustained attention.3
180754732007HTF9C gene of 22q11.21 region associates with schizophrenia having deficit-sustained attention.3
180754732007HTF9C gene of 22q11.21 region associates with schizophrenia having deficit-sustained attention.3

Citation

Dessen P

TRMT2A (tRNA methyltransferase 2 homolog A)

Atlas Genet Cytogenet Oncol Haematol. 2010-07-01

Online version: http://atlasgeneticsoncology.org/gene/51549/cancer-prone-explorer/