MAEL (maelstrom spermatogenic transposon silencer)

2010-10-01  

Identity

HGNC
MAEL
LOCATION
1q24.1
LOCUSID
84944
ALIAS
CT128,SPATA35
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84944
MIM: 611368
HGNC: 25929
Ensembl: ENSG00000143194

Variants:

dbSNP: 84944
ClinVar: 84944
TCGA: ENSG00000143194
COSMIC: MAEL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143194ENST00000367870Q96JY0
ENSG00000143194ENST00000367872Q96JY0
ENSG00000143194ENST00000367872A0A140VJP0
ENSG00000143194ENST00000447624X6RGB1
ENSG00000143194ENST00000622874E9JVC4

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
PIWI-interacting RNA (piRNA) biogenesisREACTOMER-HSA-5601884

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383010402024MAEL in human cancers and implications in prognostication and predicting benefit from immunotherapy over VEGFR/mTOR inhibitors in clear cell renal cell carcinoma: a bioinformatic analysis.0
383010402024MAEL in human cancers and implications in prognostication and predicting benefit from immunotherapy over VEGFR/mTOR inhibitors in clear cell renal cell carcinoma: a bioinformatic analysis.0
367795142023The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia.0
367795142023The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia.0
354883862022Identification of MAEL as a promoter for the drug resistance model of iPSCs derived from T-ALL.3
355138702022Maelstrom promotes tumor metastasis through regulation of FGFR4 and epithelial-mesenchymal transition in epithelial ovarian cancer.1
354883862022Identification of MAEL as a promoter for the drug resistance model of iPSCs derived from T-ALL.3
355138702022Maelstrom promotes tumor metastasis through regulation of FGFR4 and epithelial-mesenchymal transition in epithelial ovarian cancer.1
339026482021MAEL as a diagnostic marker for the early detection of esophageal squamous cell carcinoma.1
339026482021MAEL as a diagnostic marker for the early detection of esophageal squamous cell carcinoma.1
304882872020MAEL Cancer-Testis Antigen as a Diagnostic Marker in Primary Stages of Gastric Cancer with Helicobacter pylori Infection.3
304882872020MAEL Cancer-Testis Antigen as a Diagnostic Marker in Primary Stages of Gastric Cancer with Helicobacter pylori Infection.3
313866272019Long intergenic non-protein coding RNA 511 promotes the progression of osteosarcoma cells through sponging microRNA 618 to upregulate the expression of maelstrom.13
313866272019Long intergenic non-protein coding RNA 511 promotes the progression of osteosarcoma cells through sponging microRNA 618 to upregulate the expression of maelstrom.13
300824132018Maelstrom Directs Myeloid-Derived Suppressor Cells to Promote Esophageal Squamous Cell Carcinoma Progression via Activation of the Akt1/RelA/IL8 Signaling Pathway.22

Citation

Dessen P

MAEL (maelstrom spermatogenic transposon silencer)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51735/css/deep-insight-explorer/