TONSL (tonsoku like, DNA repair protein)

2010-12-01  

Identity

HGNC
LOCATION
8q24.3
LOCUSID
ALIAS
IKBR,NFKBIL2,SEMDSP
FUSION GENES

Other Information

Locus ID:

NCBI: 4796
MIM: 604546
HGNC: 7801
Ensembl: ENSG00000160949

Variants:

dbSNP: 4796
ClinVar: 4796
TCGA: ENSG00000160949
COSMIC: TONSL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160949ENST00000409379Q96HA7
ENSG00000160949ENST00000613741A0A087X1F6

Expression (GTEx)

0
5
10
15
20
25

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
366223442023MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC.4
370575952023TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer.3
372984842023Oncogenic Impact of TONSL, a Homologous Recombination Repair Protein at the Replication Fork, in Cancer Stem Cells.1
366223442023MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC.4
370575952023TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer.3
372984842023Oncogenic Impact of TONSL, a Homologous Recombination Repair Protein at the Replication Fork, in Cancer Stem Cells.1
329590512020Novel TONSL variants cause SPONASTRIME dysplasia and associate with spontaneous chromosome breaks, defective cell proliferation and apoptosis.1
329590512020Novel TONSL variants cause SPONASTRIME dysplasia and associate with spontaneous chromosome breaks, defective cell proliferation and apoptosis.1
307230512019Overexpression of TONSL might be an independent unfavorable prognostic indicator in hepatocellular carcinoma.6
307732772019Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes.13
307732782019Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia.7
311583612019A novel long non-coding RNA TONSL-AS1 regulates progression of gastric cancer via activating TONSL.4
307230512019Overexpression of TONSL might be an independent unfavorable prognostic indicator in hepatocellular carcinoma.6
307732772019Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes.13
307732782019Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia.7

Citation

Dessen P

TONSL (tonsoku like, DNA repair protein)

Atlas Genet Cytogenet Oncol Haematol. 2010-12-01

Online version: http://atlasgeneticsoncology.org/gene/51776/teaching-explorer/css/humanGenome