AZIN1 (antizyme inhibitor 1)

2010-12-01  

Identity

HGNC
AZIN1
LOCATION
8q22.3
LOCUSID
51582
ALIAS
AZI,AZI1,AZIA1,OAZI,OAZIN,ODC1L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51582
MIM: 607909
HGNC: 16432
Ensembl: ENSG00000155096

Variants:

dbSNP: 51582
ClinVar: 51582
TCGA: ENSG00000155096
COSMIC: AZIN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155096ENST00000337198O14977
ENSG00000155096ENST00000337198A0A024R9C7
ENSG00000155096ENST00000347770O14977
ENSG00000155096ENST00000347770A0A024R9C7
ENSG00000155096ENST00000518353E5RJ16
ENSG00000155096ENST00000520402E5RIB7
ENSG00000155096ENST00000521536U3KQI8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Regulation of ornithine decarboxylase (ODC)REACTOMER-HSA-350562

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372098192023RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing.1
372098192023RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing.1
353656162022A novel mechanism for A-to-I RNA-edited AZIN1 in promoting tumor angiogenesis in colorectal cancer.10
356975352022ADAR1 and AZIN1 RNA editing function as an oncogene and contributes to immortalization in endometrial cancer.7
353656162022A novel mechanism for A-to-I RNA-edited AZIN1 in promoting tumor angiogenesis in colorectal cancer.10
356975352022ADAR1 and AZIN1 RNA editing function as an oncogene and contributes to immortalization in endometrial cancer.7
305830792019Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer.29
305830792019Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer.29
300632052018Control of the polyamine biosynthesis pathway by G(2)-quadruplexes.15
305635602018Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer.36
300632052018Control of the polyamine biosynthesis pathway by G(2)-quadruplexes.15
305635602018Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer.36
288497332017RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers.34
288497332017RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers.34
258139382015A role for antizyme inhibitor in cell proliferation.11

Citation

Dessen P

AZIN1 (antizyme inhibitor 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-12-01

Online version: http://atlasgeneticsoncology.org/gene/51832/teaching-explorer/js/deep-insight-explorer/