TRPM4 (transient receptor potential cation channel subfamily M member 4)

2010-12-01  

Identity

HGNC
TRPM4
LOCATION
19q13.33
LOCUSID
54795
ALIAS
EKVP6,LTrpC4,PFHB1B,TRPM4B,hTRPM4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54795
MIM: 606936
HGNC: 17993
Ensembl: ENSG00000130529

Variants:

dbSNP: 54795
ClinVar: 54795
TCGA: ENSG00000130529
COSMIC: TRPM4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130529ENST00000252826Q8TD43
ENSG00000130529ENST00000427978Q8TD43
ENSG00000130529ENST00000595519M0QYK7
ENSG00000130529ENST00000597316M0R0H1
ENSG00000130529ENST00000598502M0QZ19
ENSG00000130529ENST00000598691M0R3H6
ENSG00000130529ENST00000598697M0QX92
ENSG00000130529ENST00000599628A0A087X0Z3

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Insulin secretionKEGGhsa04911
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
TRP channelsREACTOMER-HSA-3295583

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371289522024Exploring the role of TRPM4 in calcium-dependent triggered activity and cardiac arrhythmias.1
381034732024Transient receptor potential channel TRPM4 favors oxidized low-density lipoprotein-induced coronary endothelial cell dysfunction via a mechanism involving ferroptosis.0
371289522024Exploring the role of TRPM4 in calcium-dependent triggered activity and cardiac arrhythmias.1
381034732024Transient receptor potential channel TRPM4 favors oxidized low-density lipoprotein-induced coronary endothelial cell dysfunction via a mechanism involving ferroptosis.0
368714852023Roles of TRPM4 in immune responses in keratinocytes and identification of a novel TRPM4-activating agent.1
370378352023Influence of TRPM4 rs8104571 genotype on intracranial pressure and outcomes in African Americans with traumatic brain injury.0
375115552023The Role of TRPM4 in Cardiac Electrophysiology and Arrhythmogenesis.1
368714852023Roles of TRPM4 in immune responses in keratinocytes and identification of a novel TRPM4-activating agent.1
370378352023Influence of TRPM4 rs8104571 genotype on intracranial pressure and outcomes in African Americans with traumatic brain injury.0
375115552023The Role of TRPM4 in Cardiac Electrophysiology and Arrhythmogenesis.1
348976402022The novel TRPM4 c.448G>T variant is associated with familial conduction disorders, cardiomyopathy, and sudden cardiac death.0
354744892022Variants in genes encoding the SUR1-TRPM4 non-selective cation channel and sudden infant death syndrome (SIDS): potentially increased risk for cerebral edema.1
356814872022A Novel Role of the TRPM4 Ion Channel in Exocytosis.4
348976402022The novel TRPM4 c.448G>T variant is associated with familial conduction disorders, cardiomyopathy, and sudden cardiac death.0
354744892022Variants in genes encoding the SUR1-TRPM4 non-selective cation channel and sudden infant death syndrome (SIDS): potentially increased risk for cerebral edema.1

Citation

Dessen P

TRPM4 (transient receptor potential cation channel subfamily M member 4)

Atlas Genet Cytogenet Oncol Haematol. 2010-12-01

Online version: http://atlasgeneticsoncology.org/gene/51840/css/gene-fusions/?id=51840