EIF4H (eukaryotic translation initiation factor 4H)

2011-02-01  

Identity

HGNC
LOCATION
7q11.23
LOCUSID
ALIAS
WBSCR1,WSCR1,eIF-4H
FUSION GENES

Other Information

Locus ID:

NCBI: 7458
MIM: 603431
HGNC: 12741
Ensembl: ENSG00000106682

Variants:

dbSNP: 7458
ClinVar: 7458
TCGA: ENSG00000106682
COSMIC: EIF4H

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106682ENST00000265753Q15056
ENSG00000106682ENST00000353999Q15056

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
331303972020RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H.24
331303972020RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H.24
310233412019eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS.32
310233412019eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS.32
283513052017Overexpression of miR-519d in lung adenocarcinoma inhibits cell proliferation and invasion via the association of eIF4H.9
283513052017Overexpression of miR-519d in lung adenocarcinoma inhibits cell proliferation and invasion via the association of eIF4H.9
264986892015Key contribution of eIF4H-mediated translational control in tumor promotion.17
264986892015Key contribution of eIF4H-mediated translational control in tumor promotion.17
237766122013Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-κB.15
237766122013Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-κB.15
204739092011An alternative splicing isoform of eukaryotic initiation factor 4H promotes tumorigenesis in vivo and is a potential therapeutic target for human cancer.11
214277652011mRNA helicases: the tacticians of translational control.187
204739092011An alternative splicing isoform of eukaryotic initiation factor 4H promotes tumorigenesis in vivo and is a potential therapeutic target for human cancer.11
214277652011mRNA helicases: the tacticians of translational control.187
198479242010Detecting rare variants for complex traits using family and unrelated data.84

Citation

Dessen P

EIF4H (eukaryotic translation initiation factor 4H)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52093/teaching-explorer/gene-fusions/?id=52093