PRCP (prolylcarboxypeptidase)

2011-03-01  

Identity

HGNC
LOCATION
11q14.1
LOCUSID
ALIAS
HUMPCP,PCP
FUSION GENES

Other Information

Locus ID:

NCBI: 5547
MIM: 176785
HGNC: 9344
Ensembl: ENSG00000137509

Variants:

dbSNP: 5547
ClinVar: 5547
TCGA: ENSG00000137509
COSMIC: PRCP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137509ENST00000313010P42785
ENSG00000137509ENST00000313010A0A024R5L0
ENSG00000137509ENST00000393399P42785
ENSG00000137509ENST00000527444E9PQN3
ENSG00000137509ENST00000528082E9PLY4
ENSG00000137509ENST00000529671E9PNJ1
ENSG00000137509ENST00000531128E9PL85
ENSG00000137509ENST00000531801E9PIG4
ENSG00000137509ENST00000532809E9PNF7
ENSG00000137509ENST00000533126E9PL49
ENSG00000137509ENST00000534264E9PR42
ENSG00000137509ENST00000534396E9PQB5
ENSG00000137509ENST00000534631E9PKN6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Renin-angiotensin systemKEGGko04614
Renin-angiotensin systemKEGGhsa04614
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Intrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140837
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD20079160
PA448561benazeprilChemicalClinicalAnnotationassociatedPD20079160

References

Pubmed IDYearTitleCitations
318372032020Fast oxidation of α-melanocyte-stimulating hormone and derived peptides under laboratory conditions causes irreproducible results-Insights from studies of prolylcarboxypeptidase in human cell types.1
324480492020Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case-control study based on an isolated population.2
333196142020Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China.0
318372032020Fast oxidation of α-melanocyte-stimulating hormone and derived peptides under laboratory conditions causes irreproducible results-Insights from studies of prolylcarboxypeptidase in human cell types.1
324480492020Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case-control study based on an isolated population.2
333196142020Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China.0
288311202017Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis.8
288311202017Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis.8
274497202016Prolyl carboxypeptidase purified from human placenta: its characterization and identification as an apelin-cleaving enzyme.9
274497202016Prolyl carboxypeptidase purified from human placenta: its characterization and identification as an apelin-cleaving enzyme.9
253707942015Prolyl carboxypeptidase activity decline correlates with severity and short-term outcome in acute ischemic stroke.5
253707942015Prolyl carboxypeptidase activity decline correlates with severity and short-term outcome in acute ischemic stroke.5
253240002014Prolylcarboxypeptidase independently activates plasma prekallikrein (fletcher factor).11
253240002014Prolylcarboxypeptidase independently activates plasma prekallikrein (fletcher factor).11
226792782013Association of polymorphisms in prolylcarboxypeptidase and chymase genes with essential hypertension in the Chinese Han population.9

Citation

Dessen P

PRCP (prolylcarboxypeptidase)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52116/meetings/favicon/haematological-explorer/