ROBO3 (roundabout guidance receptor 3)

2011-03-01  

Identity

HGNC
ROBO3
LOCATION
11q24.2
LOCUSID
64221
ALIAS
HGPPS,HGPPS1,HGPS,RBIG1,RIG1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64221
MIM: 608630
HGNC: 13433
Ensembl: ENSG00000154134

Variants:

dbSNP: 64221
ClinVar: 64221
TCGA: ENSG00000154134
COSMIC: ROBO3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154134ENST00000397801Q96MS0
ENSG00000154134ENST00000538940F5GWJ5
ENSG00000154134ENST00000543966F5H0K7

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Regulation of Commissural axon pathfinding by Slit and RoboREACTOMER-HSA-428542

References

Pubmed IDYearTitleCitations
361498402023A Genetic Variant of the ROBO3 Gene is Associated With Adolescent Idiopathic Scoliosis in the Chinese Population.2
370844872023Upregulation of ROBO3 promotes proliferation, migration and adhesion of AML cells and affects the survival of AML patients.0
373309752023Early onset horizontal gaze palsy and progressive scoliosis due to a noncanonical splicing-site variant and a missense variant in the ROBO3 gene.2
361498402023A Genetic Variant of the ROBO3 Gene is Associated With Adolescent Idiopathic Scoliosis in the Chinese Population.2
370844872023Upregulation of ROBO3 promotes proliferation, migration and adhesion of AML cells and affects the survival of AML patients.0
373309752023Early onset horizontal gaze palsy and progressive scoliosis due to a noncanonical splicing-site variant and a missense variant in the ROBO3 gene.2
359933612022Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer.0
360576302022ROBO3s: a novel ROBO3 short isoform promoting breast cancer aggressiveness.0
362082302022[Expression of ROBO3 and Its Effect on Cell Proliferation and Apoptosis in Pediatric Patients with Acute Myeloid Leukemia].0
359933612022Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer.0
360576302022ROBO3s: a novel ROBO3 short isoform promoting breast cancer aggressiveness.0
362082302022[Expression of ROBO3 and Its Effect on Cell Proliferation and Apoptosis in Pediatric Patients with Acute Myeloid Leukemia].0
327055272021Introducing and Reviewing a Novel Mutation of ROBO3 in Horizontal Gaze Palsy with Progressive Scoliosis from a Chinese Family.7
335411302021High ROBO3 expression predicts poor survival in non-M3 acute myeloid leukemia.1
327055272021Introducing and Reviewing a Novel Mutation of ROBO3 in Horizontal Gaze Palsy with Progressive Scoliosis from a Chinese Family.7

Citation

Dessen P

ROBO3 (roundabout guidance receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52146/favicon/teaching-explorer/