MFF (mitochondrial fission factor)

2011-04-01  

Identity

HGNC
MFF
LOCATION
2q36.3
LOCUSID
56947
ALIAS
C2orf33,EMPF2,GL004
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56947
MIM: 614785
HGNC: 24858
Ensembl: ENSG00000168958

Variants:

dbSNP: 56947
ClinVar: 56947
TCGA: ENSG00000168958
COSMIC: MFF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168958ENST00000304593Q9GZY8
ENSG00000168958ENST00000337110Q9GZY8
ENSG00000168958ENST00000349901Q9GZY8
ENSG00000168958ENST00000353339Q9GZY8
ENSG00000168958ENST00000353339A0A024R491
ENSG00000168958ENST00000354503Q9GZY8
ENSG00000168958ENST00000392059A0A0A0MS29
ENSG00000168958ENST00000409565Q9GZY8
ENSG00000168958ENST00000409616Q9GZY8
ENSG00000168958ENST00000418961C9JU19
ENSG00000168958ENST00000423098C9JI76
ENSG00000168958ENST00000436237C9J846
ENSG00000168958ENST00000443428C9JAF1
ENSG00000168958ENST00000452930C9JHF5
ENSG00000168958ENST00000456345H7C433
ENSG00000168958ENST00000524634E9PPW6
ENSG00000168958ENST00000525195E9PPR7
ENSG00000168958ENST00000530359E9PK16
ENSG00000168958ENST00000531278E9PQX8
ENSG00000168958ENST00000534203E9PKS0

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
347506462022Mitochondrial "dysmorphology" in variant classification.0
347506462022Mitochondrial "dysmorphology" in variant classification.0
343475052021Mff oligomerization is required for Drp1 activation and synergy with actin filaments during mitochondrial division.13
344600782021Hypoxia-induced ROS promotes mitochondrial fission and cisplatin chemosensitivity via HIF-1α/Mff regulation in head and neck squamous cell carcinoma.12
343475052021Mff oligomerization is required for Drp1 activation and synergy with actin filaments during mitochondrial division.13
344600782021Hypoxia-induced ROS promotes mitochondrial fission and cisplatin chemosensitivity via HIF-1α/Mff regulation in head and neck squamous cell carcinoma.12
319416012020Mcl-1 inhibits Mff-mediated mitochondrial fragmentation and apoptosis.2
321814962020Encephalopathy due to defective mitochondrial and peroxisomal fission 2 caused by a novel MFF gene mutation in a young child.12
322241932020Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation.15
319416012020Mcl-1 inhibits Mff-mediated mitochondrial fragmentation and apoptosis.2
321814962020Encephalopathy due to defective mitochondrial and peroxisomal fission 2 caused by a novel MFF gene mutation in a young child.12
322241932020Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation.15
301919672019DUSP1 recuses diabetic nephropathy via repressing JNK-Mff-mitochondrial fission pathways.42
315339862019The phosphorylation status of Ser-637 in dynamin-related protein 1 (Drp1) does not determine Drp1 recruitment to mitochondria.45
315823802019MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer.27

Citation

Dessen P

MFF (mitochondrial fission factor)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52156/haematological-explorer/css/cancer-prone-explorer/