DEFB103A (defensin beta 103A)

2011-04-01  

Identity

HGNC
DEFB103A
LOCATION
8p23.1
LOCUSID
414325
ALIAS
BD-3,DEFB-3,DEFB103,DEFB3,HBD3,HBP-3,HBP3

Other Information

Locus ID:

NCBI: 414325
HGNC: 15967
Ensembl: ENSG00000176797

Variants:

dbSNP: 414325
ClinVar: 414325
TCGA: ENSG00000176797
COSMIC: DEFB103A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176797ENST00000314357P81534

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DefensinsREACTOMER-HSA-1461973
Beta defensinsREACTOMER-HSA-1461957
Antimicrobial peptidesREACTOMER-HSA-6803157

References

Pubmed IDYearTitleCitations
294875942018Beta-Defensin 2 and 3 Promote Bacterial Clearance of Pseudomonas aeruginosa by Inhibiting Macrophage Autophagy through Downregulation of Early Growth Response Gene-1 and c-FOS.18
297580922018Langerhans cells express human β-defensin 3: relevance for immunity during skin ageing.10
294875942018Beta-Defensin 2 and 3 Promote Bacterial Clearance of Pseudomonas aeruginosa by Inhibiting Macrophage Autophagy through Downregulation of Early Growth Response Gene-1 and c-FOS.18
297580922018Langerhans cells express human β-defensin 3: relevance for immunity during skin ageing.10
281025692017Human β-defensin 3 increases the TLR9-dependent response to bacterial DNA.17
281025692017Human β-defensin 3 increases the TLR9-dependent response to bacterial DNA.17
251964172015Potential roles of placental human beta-defensin-3 and apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G in prevention of intrauterine transmission of hepatitis B virus.9
262243242015Association between DEFB103 gene copy number variation and ankylosing spondylitis: a case-control study.2
251964172015Potential roles of placental human beta-defensin-3 and apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G in prevention of intrauterine transmission of hepatitis B virus.9
262243242015Association between DEFB103 gene copy number variation and ankylosing spondylitis: a case-control study.2
229517182013Human beta-defensin 3 induces maturation of human langerhans cell-like dendritic cells: an antimicrobial peptide that functions as an endogenous adjuvant.31
231941862013Variation in human β-defensin genes: new insights from a multi-population study.8
235110302013Human β-defensin 3 peptide is increased and redistributed in Crohn's ileitis.19
236595712013Human β-defensin-3 structure motifs that are important in CXCR4 antagonism.10
237761722013β-Defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-α production by human plasmacytoid dendritic cells, and promote inflammation.46

Citation

Dessen P

DEFB103A (defensin beta 103A)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52193/deep-insight-explorer/cancer-prone-explorer/