BTN3A1 (butyrophilin subfamily 3 member A1)

2011-06-01  

Identity

HGNC
BTN3A1
LOCATION
6p22.2
LOCUSID
11119
ALIAS
BT3.1,BTF5,BTN3.1,CD277
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11119
MIM: 613593
HGNC: 1138
Ensembl: ENSG00000026950

Variants:

dbSNP: 11119
ClinVar: 11119
TCGA: ENSG00000026950
COSMIC: BTN3A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000026950ENST00000289361O00481
ENSG00000026950ENST00000414912O00481
ENSG00000026950ENST00000425234O00481
ENSG00000026950ENST00000427334A6PVC0
ENSG00000026950ENST00000450085E7EPR2
ENSG00000026950ENST00000476549O00481
ENSG00000026950ENST00000506698E9PFB8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Butyrophilin (BTN) family interactionsREACTOMER-HSA-8851680

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
376887672024Synergistic effects of BTN3A1, SHP2, CD274, and STAT3 gene polymorphisms on the risk of systemic lupus erythematosus: a multifactorial dimensional reduction analysis.1
384509952024Association of BTN3A1 gene polymorphisms with systemic lupus erythematosus in a Chinese Han population.1
376887672024Synergistic effects of BTN3A1, SHP2, CD274, and STAT3 gene polymorphisms on the risk of systemic lupus erythematosus: a multifactorial dimensional reduction analysis.1
384509952024Association of BTN3A1 gene polymorphisms with systemic lupus erythematosus in a Chinese Han population.1
371711802023Mutations to the BTN2A1 Linker Region Impact Its Homodimerization and Its Cytoplasmic Interaction with Phospho-Antigen-Bound BTN3A1.2
376740842023Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells.12
371711802023Mutations to the BTN2A1 Linker Region Impact Its Homodimerization and Its Cytoplasmic Interaction with Phospho-Antigen-Bound BTN3A1.2
376740842023Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells.12
345458482022Elevated Expressions of BTN3A1 and RhoB in Psoriasis Vulgaris Lesions by an Immunohistochemical Study.1
349524692022Expression level of BTN3A1 on the surface of CD14(+) monocytes is a potential predictor of γδ T cell expansion efficiency.2
350813622022Ligand-induced interactions between butyrophilin 2A1 and 3A1 internal domains in the HMBPP receptor complex.16
362882862022Up-regulation of BTN3A1 on CD14(+) cells promotes Vγ9Vδ2 T cell activation in psoriasis.5
363622122022BTN3A: A Promising Immune Checkpoint for Cancer Prognosis and Treatment.5
364188902022BTN3A1 promotes tumor progression and radiation resistance in esophageal squamous cell carcinoma by regulating ULK1-mediated autophagy.6
345458482022Elevated Expressions of BTN3A1 and RhoB in Psoriasis Vulgaris Lesions by an Immunohistochemical Study.1

Citation

Dessen P

BTN3A1 (butyrophilin subfamily 3 member A1)

Atlas Genet Cytogenet Oncol Haematol. 2011-06-01

Online version: http://atlasgeneticsoncology.org/gene/52247/css/gene-fusions-explorer/