USP19 (ubiquitin specific peptidase 19)

2011-08-01  

Identity

HGNC
USP19
LOCATION
3p21.31
LOCUSID
10869
ALIAS
ZMYND9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10869
MIM: 614471
HGNC: 12617
Ensembl: ENSG00000172046

Variants:

dbSNP: 10869
ClinVar: 10869
TCGA: ENSG00000172046
COSMIC: USP19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172046ENST00000306026A0A0A0MR08
ENSG00000172046ENST00000398888O94966
ENSG00000172046ENST00000398896E7ESU0
ENSG00000172046ENST00000417901O94966
ENSG00000172046ENST00000434032O94966
ENSG00000172046ENST00000453664O94966
ENSG00000172046ENST00000465902A0A590UK03
ENSG00000172046ENST00000479073H0YB23

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

References

Pubmed IDYearTitleCitations
366469502023Opposing USP19 splice variants in TGF-β signaling and TGF-β-induced epithelial-mesenchymal transition of breast cancer cells.4
378327812023The deubiquitinating enzyme USP19 facilitates hepatocellular carcinoma progression through stabilizing YAP.2
366469502023Opposing USP19 splice variants in TGF-β signaling and TGF-β-induced epithelial-mesenchymal transition of breast cancer cells.4
378327812023The deubiquitinating enzyme USP19 facilitates hepatocellular carcinoma progression through stabilizing YAP.2
359188932022Dual role of deubiquitinating enzyme USP19 regulates mitotic progression and tumorigenesis by stabilizing survivin.7
359879692022Deubiquitinase USP19 extends the residual enzymatic activity of phenylalanine hydroxylase variants.2
359188932022Dual role of deubiquitinating enzyme USP19 regulates mitotic progression and tumorigenesis by stabilizing survivin.7
359879692022Deubiquitinase USP19 extends the residual enzymatic activity of phenylalanine hydroxylase variants.2
339787092021USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.23
339787092021USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.23
322366332020Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma.10
322366332020Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma.10
303868692019The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice.8
307007492019USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth.15
307160942019BAP1 expression is prognostic in breast and uveal melanoma but not colon cancer and is highly positively correlated with RBM15B and USP19.21

Citation

Dessen P

USP19 (ubiquitin specific peptidase 19)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52334/css/lib/case-report-explorer/