CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit)

2011-10-01  

Identity

HGNC
CHRNA6
LOCATION
8p11.21
LOCUSID
8973
ALIAS
CHNRA6

Other Information

Locus ID:

NCBI: 8973
MIM: 606888
HGNC: 15963
Ensembl: ENSG00000147434

Variants:

dbSNP: 8973
ClinVar: 8973
TCGA: ENSG00000147434
COSMIC: CHRNA6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147434ENST00000276410Q15825
ENSG00000147434ENST00000533810E9PP97
ENSG00000147434ENST00000534622Q15825

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Cholinergic synapseKEGGhsa04725
Nicotine addictionKEGGhsa05033
Nicotine addictionKEGGko05033
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Acetylcholine Binding And Downstream EventsREACTOMER-HSA-181431
Activation of Nicotinic Acetylcholine ReceptorsREACTOMER-HSA-629602
Presynaptic nicotinic acetylcholine receptorsREACTOMER-HSA-622323
Highly calcium permeable nicotinic acetylcholine receptorsREACTOMER-HSA-629597
Postsynaptic nicotinic acetylcholine receptorsREACTOMER-HSA-622327
Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsREACTOMER-HSA-629594

References

Pubmed IDYearTitleCitations
204188882010Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.368
204188882010Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.368
192599742009Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.121
189405932008In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors.118
180555612008The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco.58
180555612008The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco.58
205842122010Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.58
209238522011Expression of functional human α6β2β3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers.51
187040942009Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample.50
187040942009Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample.50

Citation

Dessen P

CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52436/haematological-explorer/