CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit)

2011-10-01  

Identity

HGNC
LOCATION
8p11.21
LOCUSID
ALIAS
CHNRA6

Other Information

Locus ID:

NCBI: 8973
MIM: 606888
HGNC: 15963
Ensembl: ENSG00000147434

Variants:

dbSNP: 8973
ClinVar: 8973
TCGA: ENSG00000147434
COSMIC: CHRNA6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147434ENST00000276410Q15825
ENSG00000147434ENST00000533810E9PP97
ENSG00000147434ENST00000534622Q15825

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Cholinergic synapseKEGGhsa04725
Nicotine addictionKEGGhsa05033
Nicotine addictionKEGGko05033
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Acetylcholine Binding And Downstream EventsREACTOMER-HSA-181431
Activation of Nicotinic Acetylcholine ReceptorsREACTOMER-HSA-629602
Presynaptic nicotinic acetylcholine receptorsREACTOMER-HSA-622323
Highly calcium permeable nicotinic acetylcholine receptorsREACTOMER-HSA-629597
Postsynaptic nicotinic acetylcholine receptorsREACTOMER-HSA-622327
Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsREACTOMER-HSA-629594

References

Pubmed IDYearTitleCitations
376801282023Involvement of CHRNA6 in the Immune Response in Lung Squamous Cell Carcinoma and its Potential as a Drug Target for the Disease.0
376801282023Involvement of CHRNA6 in the Immune Response in Lung Squamous Cell Carcinoma and its Potential as a Drug Target for the Disease.0
288519482017Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population.5
288519482017Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population.5
270858802016Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence.2
273272582016Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research.13
270858802016Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence.2
273272582016Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research.13
258238942015A genetic variant in CHRNB3-CHRNA6 increases risk of esophageal squamous cell carcinoma in Chinese populations.5
258238942015A genetic variant in CHRNB3-CHRNA6 increases risk of esophageal squamous cell carcinoma in Chinese populations.5
242534222014Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations.24
244011022014Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans.19
246756342014Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy.9
247929002014Combined effect between CHRNB3-CHRNA6 region gene variant (rs6474412) and smoking in psoriasis vulgaris severity.2
248866532014Analysis of rare variations reveals roles of amino acid residues in the N-terminal extracellular domain of nicotinic acetylcholine receptor (nAChR) alpha6 subunit in the functional expression of human alpha6*-nAChRs.5

Citation

Dessen P

CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52436/haematological-explorer/