HVCN1 (hydrogen voltage gated channel 1)

2011-10-01  

Identity

HGNC
HVCN1
LOCATION
12q24.11
LOCUSID
84329
ALIAS
HV1,VSOP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84329
MIM: 611227
HGNC: 28240
Ensembl: ENSG00000122986

Variants:

dbSNP: 84329
ClinVar: 84329
TCGA: ENSG00000122986
COSMIC: HVCN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122986ENST00000242607Q96D96
ENSG00000122986ENST00000356742Q96D96
ENSG00000122986ENST00000439744Q96D96
ENSG00000122986ENST00000546713F8W0B3
ENSG00000122986ENST00000547887F8VS40
ENSG00000122986ENST00000548312Q96D96
ENSG00000122986ENST00000549442F8VPF7
ENSG00000122986ENST00000620084Q96D96

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
ReproductionREACTOMER-HSA-1474165
FertilizationREACTOMER-HSA-1187000
Sperm Motility And TaxesREACTOMER-HSA-1300642
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382722342024Trp207 regulation of voltage-dependent activation of human H(v)1 proton channel.1
382722342024Trp207 regulation of voltage-dependent activation of human H(v)1 proton channel.1
373157912023Arachidonic acid reverses cholesterol and zinc inhibition of human voltage-gated proton channels.1
373157912023Arachidonic acid reverses cholesterol and zinc inhibition of human voltage-gated proton channels.1
338077112021Regulation of Neutrophil Functions by Hv1/VSOP Voltage-Gated Proton Channels.3
338758472021Genetic variation of staphylococcal LukAB toxin determines receptor tropism.12
341584772021Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils.21
338077112021Regulation of Neutrophil Functions by Hv1/VSOP Voltage-Gated Proton Channels.3
338758472021Genetic variation of staphylococcal LukAB toxin determines receptor tropism.12
341584772021Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils.21
323460692020The voltage-gated proton channel hHv1 is functionally expressed in human chorion-derived mesenchymal stem cells.9
323747592020Expression and function of voltage gated proton channels (Hv1) in MDA-MB-231 cells.11
327883542020Dimer interaction in the Hv1 proton channel.14
327886142020Insights on small molecule binding to the Hv1 proton channel from free energy calculations with molecular dynamics simulations.6
323460692020The voltage-gated proton channel hHv1 is functionally expressed in human chorion-derived mesenchymal stem cells.9

Citation

Dessen P

HVCN1 (hydrogen voltage gated channel 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52468/js/gene-fusions/meetings/