GRM3 (glutamate metabotropic receptor 3)

2012-01-01  

Identity

HGNC
LOCATION
7q21.11
LOCUSID
ALIAS
GLUR3,GPRC1C,MGLUR3,mGlu3
FUSION GENES

Other Information

Locus ID:

NCBI: 2913
MIM: 601115
HGNC: 4595
Ensembl: ENSG00000198822

Variants:

dbSNP: 2913
ClinVar: 2913
TCGA: ENSG00000198822
COSMIC: GRM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198822ENST00000361669Q14832
ENSG00000198822ENST00000361669A4D1D0
ENSG00000198822ENST00000421579C9JIT1
ENSG00000198822ENST00000439827Q14832
ENSG00000198822ENST00000441140C9JUH9
ENSG00000198822ENST00000454217C9J2I2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444460Heroin DependenceDiseaseClinicalAnnotation, Literature, MultilinkAnnotationassociated24498053
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD19451915, 25096017, 25209194
PA451257risperidoneChemicalClinicalAnnotationassociatedPD19451915
PA452233antipsychoticsChemicalClinicalAnnotationassociatedPD25096017, 25209194
PA452619heroinChemicalClinicalAnnotationassociated

References

Pubmed IDYearTitleCitations
342902292021Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma.10
342902292021Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma.10
319258132020Spatial transcriptomics identifies spatially dysregulated expression of GRM3 and USP47 in amyotrophic lateral sclerosis.21
325811552020Internalization of AMPA-type Glutamate Receptor in the MIN6 Pancreatic β-cell Line.2
328399352020Circ_0079593 facilitates proliferation, metastasis, glucose metabolism and inhibits apoptosis in melanoma by regulating the miR-516b/GRM3 axis.11
319258132020Spatial transcriptomics identifies spatially dysregulated expression of GRM3 and USP47 in amyotrophic lateral sclerosis.21
325811552020Internalization of AMPA-type Glutamate Receptor in the MIN6 Pancreatic β-cell Line.2
328399352020Circ_0079593 facilitates proliferation, metastasis, glucose metabolism and inhibits apoptosis in melanoma by regulating the miR-516b/GRM3 axis.11
286466172018Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling.7
301029172018Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3.15
304885812018Clinical significance of glutamate metabotropic receptors in renal cell carcinoma risk and survival.9
286466172018Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling.7
301029172018Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3.15
304885812018Clinical significance of glutamate metabotropic receptors in renal cell carcinoma risk and survival.9
281142822017The miR-487b-3p/GRM3/TGFβ signaling axis is an important regulator of colon cancer tumorigenesis.15

Citation

Dessen P

GRM3 (glutamate metabotropic receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52514/css/lib/case-report-explorer/