UBA2 (ubiquitin like modifier activating enzyme 2)

2012-02-01  

Identity

HGNC
UBA2
LOCATION
19q13.11
LOCUSID
10054
ALIAS
ARX,HRIHFB2115,SAE2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10054
MIM: 613295
HGNC: 30661
Ensembl: ENSG00000126261

Variants:

dbSNP: 10054
ClinVar: 10054
TCGA: ENSG00000126261
COSMIC: UBA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126261ENST00000246548Q9UBT2
ENSG00000126261ENST00000439527Q9UBT2
ENSG00000126261ENST00000586313K7ES38
ENSG00000126261ENST00000590048K7EPL2
ENSG00000126261ENST00000591016K7ESK7
ENSG00000126261ENST00000592791U3KQ93
ENSG00000126261ENST00000607361U3KQ55

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
Processing and activation of SUMOREACTOMER-HSA-3215018
SUMO is conjugated to E1 (UBA2:SAE1)REACTOMER-HSA-3065676
SUMO is transferred from E1 to E2 (UBE2I, UBC9)REACTOMER-HSA-3065678

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386821832024UBA2 as a Prognostic Biomarker and Potential Therapeutic Target in Glioma.0
386821832024UBA2 as a Prognostic Biomarker and Potential Therapeutic Target in Glioma.0
344674712022UBA2 promotes the progression of renal cell carcinoma by suppressing the p53 signaling.0
344674712022UBA2 promotes the progression of renal cell carcinoma by suppressing the p53 signaling.0
339796482021Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics.11
340401892021UBA2 variants underlie a recognizable syndrome with variable aplasia cutis congenita and ectrodactyly.5
341594002021Genome sequencing in families with congenital limb malformations.8
339796482021Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics.11
340401892021UBA2 variants underlie a recognizable syndrome with variable aplasia cutis congenita and ectrodactyly.5
341594002021Genome sequencing in families with congenital limb malformations.8
329388302020Increased SUMO-activating enzyme SAE1/UBA2 promotes glycolysis and pathogenic behavior of rheumatoid fibroblast-like synoviocytes.14
330084872020UBA2 activates Wnt/β-catenin signaling pathway during protection of R28 retinal precursor cells from hypoxia by extracellular vesicles derived from placental mesenchymal stem cells.7
329388302020Increased SUMO-activating enzyme SAE1/UBA2 promotes glycolysis and pathogenic behavior of rheumatoid fibroblast-like synoviocytes.14
330084872020UBA2 activates Wnt/β-catenin signaling pathway during protection of R28 retinal precursor cells from hypoxia by extracellular vesicles derived from placental mesenchymal stem cells.7
308485002019Identifying UBA2 as a proliferation and cell cycle regulator in lung cancer A549 cells.11

Citation

Dessen P

UBA2 (ubiquitin like modifier activating enzyme 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52587/meetings/cancer-prone-explorer/