KCNA4 (potassium voltage-gated channel subfamily A member 4)

2012-03-01  

Identity

HGNC
LOCATION
11p14.1
LOCUSID
ALIAS
HBK4,HK1,HPCN2,HUKII,KCNA4L,KCNA8,KV1.4,MCIDDS,PCN2

Other Information

Locus ID:

NCBI: 3739
MIM: 176266
HGNC: 6222
Ensembl: ENSG00000182255

Variants:

dbSNP: 3739
ClinVar: 3739
TCGA: ENSG00000182255
COSMIC: KCNA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182255ENST00000328224P22459

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Voltage gated Potassium channelsREACTOMER-HSA-1296072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
366936152023miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure.3
366936152023miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure.3
354390542022An epilepsy-associated K(V)1.2 charge-transfer-center mutation impairs K(V)1.2 and K(V)1.4 trafficking.2
354390542022An epilepsy-associated K(V)1.2 charge-transfer-center mutation impairs K(V)1.2 and K(V)1.4 trafficking.2
340382432021Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.4
340382432021Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.4
308120342019KCNA4 Gene Variant is Auxiliary in Endurance Running Performance Level.0
308120342019KCNA4 Gene Variant is Auxiliary in Endurance Running Performance Level.0
225609312012K+ channel alterations in the progression of experimental autoimmune encephalomyelitis.23
225609312012K+ channel alterations in the progression of experimental autoimmune encephalomyelitis.23
213073452011Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain.17
219450242011Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis.17
213073452011Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain.17
219450242011Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis.17
199618282010N-glycans modulate K(v)1.5 gating but have no effect on K(v)1.4 gating.13

Citation

Dessen P

KCNA4 (potassium voltage-gated channel subfamily A member 4)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52634/js/lib/haematological-explorer/