KCNA4 (potassium voltage-gated channel subfamily A member 4)

2012-03-01 Affiliation

Identity

HGNC

KCNA4

LOCATION

11p14.1

LOCUSID

3739

ALIAS

HBK4,HK1,HPCN2,HUKII,KCNA4L,KCNA8,KV1.4,MCIDDS,PCN2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3739
MIM: 176266
HGNC: 6222
Ensembl: ENSG00000182255

Variants:

dbSNP: 3739
ClinVar: 3739
TCGA: ENSG00000182255
COSMIC: KCNA4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000182255	ENST00000328224	P22459

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuronal System	REACTOME	R-HSA-112316
Potassium Channels	REACTOME	R-HSA-1296071
Voltage gated Potassium channels	REACTOME	R-HSA-1296072

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36693615	2023	miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure.	3
36693615	2023	miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure.	3
35439054	2022	An epilepsy-associated K(V)1.2 charge-transfer-center mutation impairs K(V)1.2 and K(V)1.4 trafficking.	2
35439054	2022	An epilepsy-associated K(V)1.2 charge-transfer-center mutation impairs K(V)1.2 and K(V)1.4 trafficking.	2
34038243	2021	Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.	4
34038243	2021	Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.	4
30812034	2019	KCNA4 Gene Variant is Auxiliary in Endurance Running Performance Level.	0
30812034	2019	KCNA4 Gene Variant is Auxiliary in Endurance Running Performance Level.	0
22560931	2012	K+ channel alterations in the progression of experimental autoimmune encephalomyelitis.	23
22560931	2012	K+ channel alterations in the progression of experimental autoimmune encephalomyelitis.	23
21307345	2011	Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain.	17
21945024	2011	Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis.	17
21307345	2011	Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain.	17
21945024	2011	Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis.	17
19961828	2010	N-glycans modulate K(v)1.5 gating but have no effect on K(v)1.4 gating.	13

Citation

Dessen P

KCNA4 (potassium voltage-gated channel subfamily A member 4)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52634/js/lib/haematological-explorer/