CDH5 (cadherin 5)

2012-04-01  

Identity

HGNC
CDH5
LOCATION
16q21
LOCUSID
1003
ALIAS
7B4,CD144
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1003
MIM: 601120
HGNC: 1764
Ensembl: ENSG00000179776

Variants:

dbSNP: 1003
ClinVar: 1003
TCGA: ENSG00000179776
COSMIC: CDH5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179776ENST00000341529P33151
ENSG00000179776ENST00000539168B4DTR2
ENSG00000179776ENST00000562048H3BPG1
ENSG00000179776ENST00000563425I3L1J2
ENSG00000179776ENST00000565334H3BR11
ENSG00000179776ENST00000568023H3BQ82
ENSG00000179776ENST00000568155H3BR64
ENSG00000179776ENST00000614547P33151
ENSG00000179776ENST00000649567P33151

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Leukocyte transendothelial migrationKEGGhsa04670
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated vascular permeabilityREACTOMER-HSA-5218920
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Adherens junctions interactionsREACTOMER-HSA-418990
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378378202024Fibrinogen Fragment X Mediates Endothelial Barrier Disruption via Suppression of VE-Cadherin.1
378378202024Fibrinogen Fragment X Mediates Endothelial Barrier Disruption via Suppression of VE-Cadherin.1
369460502023[Porphyromonas gingivalis infection causes umbilical vein endothelial barrier dysfunction in vitro by down-regulating ZO-1, occludin and VE-cadherin expression].1
372982962023VE-Cadherin in Cancer-Associated Angiogenesis: A Deceptive Strategy of Blood Vessel Formation.3
378090802023A comprehensive pan-cancer analysis of CDH5 in immunological response.3
378326552023HMGB1 Release Induced by EV71 Infection Exacerbates Blood-Brain Barrier Disruption via VE-cadherin Phosphorylation.1
380156262023TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization.2
369460502023[Porphyromonas gingivalis infection causes umbilical vein endothelial barrier dysfunction in vitro by down-regulating ZO-1, occludin and VE-cadherin expression].1
372982962023VE-Cadherin in Cancer-Associated Angiogenesis: A Deceptive Strategy of Blood Vessel Formation.3
378090802023A comprehensive pan-cancer analysis of CDH5 in immunological response.3
378326552023HMGB1 Release Induced by EV71 Infection Exacerbates Blood-Brain Barrier Disruption via VE-cadherin Phosphorylation.1
380156262023TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization.2
348824812022CDH5, a Possible New Candidate Gene for Genetic Testing of Lymphedema.2
348824812022CDH5, a Possible New Candidate Gene for Genetic Testing of Lymphedema.2
329919502021The VE-Cadherin/β-catenin signalling axis regulates immune cell infiltration into tumours.14

Citation

Dessen P

CDH5 (cadherin 5)

Atlas Genet Cytogenet Oncol Haematol. 2012-04-01

Online version: http://atlasgeneticsoncology.org/gene/52671/tumors-explorer/gene-fusions-explorer/meetings/