SCARB2 (scavenger receptor class B member 2)

2012-04-01  

Identity

HGNC
SCARB2
LOCATION
4q21.1
LOCUSID
950
ALIAS
AMRF,CD36L2,EPM4,HLGP85,LGP85,LIMP-2,LIMPII,SR-BII
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 950
MIM: 602257
HGNC: 1665
Ensembl: ENSG00000138760

Variants:

dbSNP: 950
ClinVar: 950
TCGA: ENSG00000138760
COSMIC: SCARB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138760ENST00000264896Q14108
ENSG00000138760ENST00000264896A0A024RDG6
ENSG00000138760ENST00000452464Q14108
ENSG00000138760ENST00000509994D6RDG0
ENSG00000138760ENST00000638295A0A1W2PRF6
ENSG00000138760ENST00000638603A0A1W2PPU6
ENSG00000138760ENST00000638663A0A1W2PPX5
ENSG00000138760ENST00000639145A0A1W2PS43
ENSG00000138760ENST00000639300A0A1W2PSE4
ENSG00000138760ENST00000639715A0A1W2PNX7
ENSG00000138760ENST00000639738A0A1W2PQL5
ENSG00000138760ENST00000640341A0A1W2PS70
ENSG00000138760ENST00000640634A0A1W2PRS1
ENSG00000138760ENST00000640640A0A1W2PQR6
ENSG00000138760ENST00000640880A0A1W2PPX6
ENSG00000138760ENST00000640957A0A1W2PQB7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382318762024Lysosomal membrane proteins LAMP1 and LIMP2 are segregated in the Golgi apparatus independently of their clathrin adaptor binding motif.0
383590792024Enterovirus A71 does not meet the uncoating receptor SCARB2 at the cell surface.1
382318762024Lysosomal membrane proteins LAMP1 and LIMP2 are segregated in the Golgi apparatus independently of their clathrin adaptor binding motif.0
383590792024Enterovirus A71 does not meet the uncoating receptor SCARB2 at the cell surface.1
370783582023The effects of SCARB2 and SELPLG gene polymorphisms on EV71 infection in hand, foot and mouth disease.0
371129122023Human SCARB2 Acts as a Cellular Associator for Helping Coxsackieviruses A10 Infection.0
372911502023LIMP-2 enhances cancer stem-like cell properties by promoting autophagy-induced GSK3β degradation in head and neck squamous cell carcinoma.4
376402602023Knockdown LIMP2 inhibits colorectal cancer cells migration, invasion, and metastasis.1
377399362023SCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity.3
370783582023The effects of SCARB2 and SELPLG gene polymorphisms on EV71 infection in hand, foot and mouth disease.0
371129122023Human SCARB2 Acts as a Cellular Associator for Helping Coxsackieviruses A10 Infection.0
372911502023LIMP-2 enhances cancer stem-like cell properties by promoting autophagy-induced GSK3β degradation in head and neck squamous cell carcinoma.4
376402602023Knockdown LIMP2 inhibits colorectal cancer cells migration, invasion, and metastasis.1
377399362023SCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity.3
359873412022LIMP2 gene, evolutionarily conserved regulation by TFE3, relieves lysosomal stress induced by cholesterol.1

Citation

Dessen P

SCARB2 (scavenger receptor class B member 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-04-01

Online version: http://atlasgeneticsoncology.org/gene/52675/js/css/teaching-explorer/