ARFGAP3 (ADP ribosylation factor GTPase activating protein 3)

2012-05-01  

Identity

HGNC
ARFGAP3
LOCATION
22q13.2
LOCUSID
26286
ALIAS
ARFGAP1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26286
MIM: 612439
HGNC: 661
Ensembl: ENSG00000242247

Variants:

dbSNP: 26286
ClinVar: 26286
TCGA: ENSG00000242247
COSMIC: ARFGAP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000242247ENST00000263245Q9NP61
ENSG00000242247ENST00000263245A0A024R4U0
ENSG00000242247ENST00000435208B0QYV9
ENSG00000242247ENST00000437119Q9NP61
ENSG00000242247ENST00000453516H0Y6A0
ENSG00000242247ENST00000454099B0QYV8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
318688322021Expression of ArfGAP3 in Vaginal Anterior Wall of Patients With Pelvic Floor Organ Prolapse in Pelvic Organ Prolapse and Non-Pelvic Organ Prolapse Patients.0
318688322021Expression of ArfGAP3 in Vaginal Anterior Wall of Patients With Pelvic Floor Organ Prolapse in Pelvic Organ Prolapse and Non-Pelvic Organ Prolapse Patients.0
240762382013ArfGAP3 regulates the transport of cation-independent mannose 6-phosphate receptor in the post-Golgi compartment.16
240762382013ArfGAP3 regulates the transport of cation-independent mannose 6-phosphate receptor in the post-Golgi compartment.16
216478752012ARFGAP3, an androgen target gene, promotes prostate cancer cell proliferation and migration.15
216478752012ARFGAP3, an androgen target gene, promotes prostate cancer cell proliferation and migration.15
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
192995152009Three homologous ArfGAPs participate in coat protein I-mediated transport.22
192995152009Three homologous ArfGAPs participate in coat protein I-mediated transport.22
190153192008Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking.37
190153192008Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking.37
177608592007Two human ARFGAPs associated with COP-I-coated vesicles.35
177608592007Two human ARFGAPs associated with COP-I-coated vesicles.35

Citation

Dessen P

ARFGAP3 (ADP ribosylation factor GTPase activating protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-05-01

Online version: http://atlasgeneticsoncology.org/gene/52719/tumors-explorer/js/gene-fusions-explorer/