DPP6 (dipeptidyl peptidase like 6)

2012-09-01  

Identity

HGNC
DPP6
LOCATION
7q36.2
LOCUSID
1804
ALIAS
DPL1,DPPX,MRD33,VF2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1804
MIM: 126141
HGNC: 3010
Ensembl: ENSG00000130226

Variants:

dbSNP: 1804
ClinVar: 1804
TCGA: ENSG00000130226
COSMIC: DPP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130226ENST00000332007P42658
ENSG00000130226ENST00000377770P42658
ENSG00000130226ENST00000404039E9PF59
ENSG00000130226ENST00000406326Q8IYG9
ENSG00000130226ENST00000427557E9PDL2
ENSG00000130226ENST00000619756A0A087WTG7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD32451486
PA448073ethanolChemicalClinicalAnnotationassociatedPD32451486
PA449841haloperidolChemicalMultilinkAnnotationassociated27023437

References

Pubmed IDYearTitleCitations
383813922024Association between DPP6 gene rs10260404 polymorphism and increased risk of sporadic amyotrophic lateral sclerosis (sALS): a meta-analysis.0
383813922024Association between DPP6 gene rs10260404 polymorphism and increased risk of sporadic amyotrophic lateral sclerosis (sALS): a meta-analysis.0
327011432020Dipeptidyl peptidase like 6 promoter methylation is a potential prognostic biomarker for pancreatic ductal adenocarcinoma.5
331435492020Neuronal Differentiation of Induced Pluripotent Stem Cells from Schizophrenia Patients in Two-Dimensional and in Three-Dimensional Cultures Reveals Increased Expression of the Kv4.2 Subunit DPP6 That Contributes to Decreased Neuronal Activity.9
327011432020Dipeptidyl peptidase like 6 promoter methylation is a potential prognostic biomarker for pancreatic ductal adenocarcinoma.5
331435492020Neuronal Differentiation of Induced Pluripotent Stem Cells from Schizophrenia Patients in Two-Dimensional and in Three-Dimensional Cultures Reveals Increased Expression of the Kv4.2 Subunit DPP6 That Contributes to Decreased Neuronal Activity.9
308749222019Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability.26
314762892019A novel DPP6 variant in Chinese families causes early repolarization syndrome.1
308749222019Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability.26
314762892019A novel DPP6 variant in Chinese families causes early repolarization syndrome.1
294747312018A novel mutation of dipeptidyl aminopeptidase-like protein-6 in a family with suspicious idiopathic ventricular fibrillation.2
294747312018A novel mutation of dipeptidyl aminopeptidase-like protein-6 in a family with suspicious idiopathic ventricular fibrillation.2
277599172017Implication of LRRC4C and DPP6 in neurodevelopmental disorders.25
277599172017Implication of LRRC4C and DPP6 in neurodevelopmental disorders.25
266816092016Detailed characterization of familial idiopathic ventricular fibrillation linked to the DPP6 locus.16

Citation

Dessen P

DPP6 (dipeptidyl peptidase like 6)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52851/gene-fusions/haematological-explorer/case-report-explorer/