ADPGK (ADP dependent glucokinase)

2012-09-01  

Identity

HGNC
ADPGK
LOCATION
15q24.1
LOCUSID
83440
ALIAS
2610017G09Rik,ADP-GK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83440
MIM: 611861
HGNC: 25250
Ensembl: ENSG00000159322

Variants:

dbSNP: 83440
ClinVar: 83440
TCGA: ENSG00000159322
COSMIC: ADPGK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159322ENST00000311669Q9BRR6
ENSG00000159322ENST00000456471Q9BRR6
ENSG00000159322ENST00000562286H3BTH4
ENSG00000159322ENST00000562823Q9BRR6
ENSG00000159322ENST00000563907H3BRS6
ENSG00000159322ENST00000565814H3BU35
ENSG00000159322ENST00000567941Q9BRR6
ENSG00000159322ENST00000569517Q9BRR6
ENSG00000159322ENST00000569534H3BN66
ENSG00000159322ENST00000569693H3BUC3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Glycolysis / GluconeogenesisKEGGhsa00010
Metabolic pathwaysKEGGhsa01100
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGhsa_M00001
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGM00001
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370848042023Kinetic characterization and phylogenetic analysis of human ADP-dependent glucokinase reveal new insights into its regulatory properties.0
370848042023Kinetic characterization and phylogenetic analysis of human ADP-dependent glucokinase reveal new insights into its regulatory properties.0
321965892020ADPGK-AS1 promotes the progression of colorectal cancer via sponging miR-525 to upregulate FUT1.10
327886802020ADP-dependent glucokinase as a novel onco-target for haematological malignancies.2
321965892020ADPGK-AS1 promotes the progression of colorectal cancer via sponging miR-525 to upregulate FUT1.10
327886802020ADP-dependent glucokinase as a novel onco-target for haematological malignancies.2
315827622019ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing.9
315827622019ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing.9
265552632016The Structural and Functional Characterization of Mammalian ADP-dependent Glucokinase.11
265552632016The Structural and Functional Characterization of Mammalian ADP-dependent Glucokinase.11
237990032013Zinc finger nuclease mediated knockout of ADP-dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism.8
237990032013Zinc finger nuclease mediated knockout of ADP-dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism.8
222190262012Expression and role in glycolysis of human ADP-dependent glucokinase.19
222190262012Expression and role in glycolysis of human ADP-dependent glucokinase.19
199037542010Clinical heterogeneity in monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY).17

Citation

Dessen P

ADPGK (ADP dependent glucokinase)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52891/haematological-explorer/