AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3)

2012-11-01  

Identity

HGNC
AGAP3
LOCATION
7q36.1
LOCUSID
116988
ALIAS
AGAP-3,CENTG3,CRAG,MRIP-1,cnt-g3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 116988
MIM: 616813
HGNC: 16923
Ensembl: ENSG00000133612

Variants:

dbSNP: 116988
ClinVar: 116988
TCGA: ENSG00000133612
COSMIC: AGAP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133612ENST00000335367E7ESL9
ENSG00000133612ENST00000397238Q96P47
ENSG00000133612ENST00000461065H0Y873
ENSG00000133612ENST00000463381Q96P47
ENSG00000133612ENST00000467724H7C5G0
ENSG00000133612ENST00000468796H7C4U6
ENSG00000133612ENST00000469901H7C4F1
ENSG00000133612ENST00000473312Q96P47
ENSG00000133612ENST00000479901C9J975
ENSG00000133612ENST00000622464Q96P47
ENSG00000133612ENST00000622464A0A090N7Y0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380711092024HUNK inhibits cargo uptake and lysosomal traffic in the caveolar pathway via the AGAP3/ARF6.0
380711092024HUNK inhibits cargo uptake and lysosomal traffic in the caveolar pathway via the AGAP3/ARF6.0
343984952021Gastrointestinal stromal tumors with BRAF gene fusions. A report of two cases showing low or absent KIT expression resulting in diagnostic pitfalls.7
343984952021Gastrointestinal stromal tumors with BRAF gene fusions. A report of two cases showing low or absent KIT expression resulting in diagnostic pitfalls.7
305914452019CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis.8
305914452019CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis.8
239045962013AGAP3 and Arf6 regulate trafficking of AMPA receptors and synaptic plasticity.36
239045962013AGAP3 and Arf6 regulate trafficking of AMPA receptors and synaptic plasticity.36
145062642003Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA.40
145062642003Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA.40

Citation

Dessen P

AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52940/teaching-explorer/meetings/