CPSF6 (cleavage and polyadenylation specific factor 6)

2012-11-01  

Identity

HGNC
CPSF6
LOCATION
12q15
LOCUSID
11052
ALIAS
CFIM,CFIM68,CFIM72,HPBRII-4,HPBRII-7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11052
MIM: 604979
HGNC: 13871
Ensembl: ENSG00000111605

Variants:

dbSNP: 11052
ClinVar: 11052
TCGA: ENSG00000111605
COSMIC: CPSF6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111605ENST00000266679Q16630
ENSG00000111605ENST00000435070Q16630
ENSG00000111605ENST00000456847F8WJN3
ENSG00000111605ENST00000550075F8W084
ENSG00000111605ENST00000551516F8VNP8
ENSG00000111605ENST00000650046A0A3B3ISW1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by FGFR in diseaseREACTOMER-HSA-1226099
Signaling by FGFR1 in diseaseREACTOMER-HSA-5655302
FGFR1 mutant receptor activationREACTOMER-HSA-1839124
Signaling by cytosolic FGFR1 fusion mutantsREACTOMER-HSA-1839117

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384167822024Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses.0
384167822024Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses.0
373793162023Alternative polyadenylation factor CPSF6 regulates temperature compensation of the mammalian circadian clock.0
374147872023Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection.3
377779642023CPSF6 regulates alternative polyadenylation and proliferation of cancer cells through phase separation.4
373793162023Alternative polyadenylation factor CPSF6 regulates temperature compensation of the mammalian circadian clock.0
374147872023Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection.3
377779642023CPSF6 regulates alternative polyadenylation and proliferation of cancer cells through phase separation.4
364463612022The roles of CPSF6 in proliferation, apoptosis and tumorigenicity of lung adenocarcinoma.4
364463612022The roles of CPSF6 in proliferation, apoptosis and tumorigenicity of lung adenocarcinoma.4
336485522021CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression.22
337580832021Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner.25
339493102021SAM homeostasis is regulated by CFI(m)-mediated splicing of MAT2A.18
341544142021Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal.2
342173122021Ribonucleic acid-binding protein CPSF6 promotes glycolysis and suppresses apoptosis in hepatocellular carcinoma cells by inhibiting the BTG2 expression.4

Citation

Dessen P

CPSF6 (cleavage and polyadenylation specific factor 6)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52984/img/gene-fusions/tumors-explorer/