EIF3K (eukaryotic translation initiation factor 3 subunit K)

2012-11-01 Affiliation

Identity

HGNC

EIF3K

LOCATION

19q13.2

LOCUSID

27335

ALIAS

ARG134,EIF3-p28,EIF3S12,HSPC029,M9,MSTP001,PLAC-24,PLAC24,PRO1474,PTD001

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 27335
MIM: 609596
HGNC: 24656
Ensembl: ENSG00000178982

Variants:

dbSNP: 27335
ClinVar: 27335
TCGA: ENSG00000178982
COSMIC: EIF3K

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000178982	ENST00000248342	Q9UBQ5
ENSG00000178982	ENST00000538434	B4DQ48
ENSG00000178982	ENST00000545173	Q9UBQ5
ENSG00000178982	ENST00000588934	K7ES31
ENSG00000178982	ENST00000591409	K7EQM4
ENSG00000178982	ENST00000592558	K7ERF1
ENSG00000178982	ENST00000593149	K7EK53
ENSG00000178982	ENST00000614624	A0A087WVB9

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Translation	REACTOME	R-HSA-72766
Eukaryotic Translation Initiation	REACTOME	R-HSA-72613
Cap-dependent Translation Initiation	REACTOME	R-HSA-72737
Formation of a pool of free 40S subunits	REACTOME	R-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complex	REACTOME	R-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	REACTOME	R-HSA-72662
Translation initiation complex formation	REACTOME	R-HSA-72649
Ribosomal scanning and start codon recognition	REACTOME	R-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunit	REACTOME	R-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expression	REACTOME	R-HSA-156827
Gene Expression	REACTOME	R-HSA-74160

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
31863585	2020	Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively.	17
31863585	2020	Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively.	17
24036361	2013	The translation initiation factor 3 subunit eIF3K interacts with PML and associates with PML nuclear bodies.	8
24036361	2013	The translation initiation factor 3 subunit eIF3K interacts with PML and associates with PML nuclear bodies.	8
18577580	2008	eIF3k regulates apoptosis in epithelial cells by releasing caspase 3 from keratin-containing inclusions.	19
18577580	2008	eIF3k regulates apoptosis in epithelial cells by releasing caspase 3 from keratin-containing inclusions.	19
15180986	2004	Crystal structure of human eIF3k, the first structure of eIF3 subunits.	32
15327989	2004	Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3.	11
15180986	2004	Crystal structure of human eIF3k, the first structure of eIF3 subunits.	32
15327989	2004	Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3.	11
12006665	2002	PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact.	8
12006665	2002	PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact.	8

Citation

Dessen P

EIF3K (eukaryotic translation initiation factor 3 subunit K)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52996/css/humanGenome