TLE5 (TLE family member 5, transcriptional modulator)

2012-12-01  

Identity

HGNC
TLE5
LOCATION
19p13.3
LOCUSID
166
ALIAS
AES,AES-1,AES-2,ESP1,GRG,GRG5,Grg-5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 166
MIM: 600188
HGNC: 307
Ensembl: ENSG00000104964

Variants:

dbSNP: 166
ClinVar: 166
TCGA: ENSG00000104964
COSMIC: TLE5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104964ENST00000221561Q08117
ENSG00000104964ENST00000327141Q08117
ENSG00000104964ENST00000585557K7ELQ8
ENSG00000104964ENST00000586742K7ELE3
ENSG00000104964ENST00000586839K7EQH5

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Repression of WNT target genesREACTOMER-HSA-4641265

References

Pubmed IDYearTitleCitations
378006252023Unrevealed roles of extracellular enolase‑1 (ENO1) in promoting glycolysis and pro‑cancer activities in multiple myeloma via hypoxia‑inducible factor 1α.2
378006252023Unrevealed roles of extracellular enolase‑1 (ENO1) in promoting glycolysis and pro‑cancer activities in multiple myeloma via hypoxia‑inducible factor 1α.2
337540692021The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer.12
337540692021The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer.12
281783912017Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer.13
281783912017Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer.13
262291112016Characterization of Aes nuclear foci in colorectal cancer cells.5
275611712016Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2.12
262291112016Characterization of Aes nuclear foci in colorectal cancer cells.5
275611712016Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2.12
265492282015Repression of HNF1α-mediated transcription by amino-terminal enhancer of split (AES).3
265492282015Repression of HNF1α-mediated transcription by amino-terminal enhancer of split (AES).3
235465942013Suppression of RND3 activity by AES downregulation promotes cancer cell proliferation and invasion.9
237321152013A PROP1-binding factor, AES cloned by yeast two-hybrid assay represses PROP1-induced Pit-1 gene expression.0
238408762013GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos.8

Citation

Dessen P

TLE5 (TLE family member 5, transcriptional modulator)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53080/css/lib/js/lib/haematological-explorer/