ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide)

2012-12-01  

Identity

HGNC
ADH1A
LOCATION
4q23
LOCUSID
124
ALIAS
ADH1

Other Information

Locus ID:

NCBI: 124
MIM: 103700
HGNC: 249
Ensembl: ENSG00000187758

Variants:

dbSNP: 124
ClinVar: 124
TCGA: ENSG00000187758
COSMIC: ADH1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187758ENST00000209668P07327

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Fatty acid degradationKEGGko00071
Tyrosine metabolismKEGGko00350
Retinol metabolismKEGGko00830
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glycolysis / GluconeogenesisKEGGhsa00010
Fatty acid degradationKEGGhsa00071
Tyrosine metabolismKEGGhsa00350
Retinol metabolismKEGGhsa00830
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Metabolic pathwaysKEGGhsa01100
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Ethanol oxidationREACTOMER-HSA-71384
Abacavir transport and metabolismREACTOMER-HSA-2161522
Abacavir metabolismREACTOMER-HSA-2161541

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166155185rs1234612VariantVipGeneassociated
PA166156497rs975833VariantVipGeneassociated
PA166186245acetaldehydeChemicalClinicalAnnotationassociatedPK31002879
PA443309AlcoholismDiseaseVipGeneassociated
PA448004abacavirChemicalPathwayassociated24625462
PA448073ethanolChemicalVipGeneassociated

References

Pubmed IDYearTitleCitations
347428562022Contrary to consensus, oxidation of ethanol by human alcohol dehydrogenase (ADH) 1A is activated by ATP.0
347428562022Contrary to consensus, oxidation of ethanol by human alcohol dehydrogenase (ADH) 1A is activated by ATP.0
310028792019The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea.6
310028792019The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea.6
292487122018Genetic variant repressing ADH1A expression confers susceptibility to esophageal squamous-cell carcinoma.4
297390652018The Activity of Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase in the Sera of Patients with Autoimmune Hepatitis.2
292487122018Genetic variant repressing ADH1A expression confers susceptibility to esophageal squamous-cell carcinoma.4
297390652018The Activity of Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase in the Sera of Patients with Autoimmune Hepatitis.2
288709182017The Diagnostic Significance of Serum Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase Activity in Prostate Cancer Patients.3
288709182017The Diagnostic Significance of Serum Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase Activity in Prostate Cancer Patients.3
270860372016The diagnostic significance of serum alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase activity in renal cell cancer patients.2
270860372016The diagnostic significance of serum alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase activity in renal cell cancer patients.2
247620662014Changes in aldehyde dehydrogenase-1 expression during neoadjuvant chemotherapy predict outcome in locally advanced breast cancer.28
247620662014Changes in aldehyde dehydrogenase-1 expression during neoadjuvant chemotherapy predict outcome in locally advanced breast cancer.28
234681742013Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism.13

Citation

Dessen P

ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53093/favicon/favicon/manifest.json