GIT1 (GIT ArfGAP 1)

2012-12-01  

Identity

HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 28964
MIM: 608434
HGNC: 4272
Ensembl: ENSG00000108262

Variants:

dbSNP: 28964
ClinVar: 28964
TCGA: ENSG00000108262
COSMIC: GIT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108262ENST00000225394Q9Y2X7
ENSG00000108262ENST00000335356E7EVC2
ENSG00000108262ENST00000394869Q9Y2X7
ENSG00000108262ENST00000577466K7EIX6
ENSG00000108262ENST00000578266J3QL89
ENSG00000108262ENST00000578670J3QQI0
ENSG00000108262ENST00000579937J3QRU8
ENSG00000108262ENST00000581348A0A0C4DGN6
ENSG00000108262ENST00000583413K7EN79
ENSG00000108262ENST00000585148J3QLH1

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Regulation of actin cytoskeletonKEGGhsa04810
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
Ephrin signalingREACTOMER-HSA-3928664

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
369946872023Pan-cancer analysis of the oncogenic effects of G-protein-coupled receptor kinase-interacting protein-1 and validation on liver hepatocellular carcinoma.0
369946872023Pan-cancer analysis of the oncogenic effects of G-protein-coupled receptor kinase-interacting protein-1 and validation on liver hepatocellular carcinoma.0
353183022022GIT1 protects against breast cancer growth through negative regulation of Notch.4
353183022022GIT1 protects against breast cancer growth through negative regulation of Notch.4
332583892021GIT1 overexpression promotes epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma.21
337524802021Exosomal miR-122-5p inhibits tumorigenicity of gastric cancer by downregulating GIT1.10
332583892021GIT1 overexpression promotes epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma.21
337524802021Exosomal miR-122-5p inhibits tumorigenicity of gastric cancer by downregulating GIT1.10
304174662019Alternative RNA splicing of the GIT1 gene is associated with neuroendocrine prostate cancer.12
315023022019GIT1 regulates angiogenic factor secretion in bone marrow mesenchymal stem cells via NF-κB/Notch signalling to promote angiogenesis.12
318320022019MicroRNA-760 acts as a tumor suppressor in gastric cancer development via inhibiting G-protein-coupled receptor kinase interacting protein-1 transcription.6
304174662019Alternative RNA splicing of the GIT1 gene is associated with neuroendocrine prostate cancer.12
315023022019GIT1 regulates angiogenic factor secretion in bone marrow mesenchymal stem cells via NF-κB/Notch signalling to promote angiogenesis.12
318320022019MicroRNA-760 acts as a tumor suppressor in gastric cancer development via inhibiting G-protein-coupled receptor kinase interacting protein-1 transcription.6
291919422018β-PIX plays an important role in regulation of intestinal epithelial restitution by interacting with GIT1 and Rac1 after wounding.7

Citation

Dessen P

GIT1 (GIT ArfGAP 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53101/css/css/gene-fusions-explorer/