GIT1 (GIT ArfGAP 1)

2012-12-01  

Identity

HGNC
GIT1
LOCATION
17q11.2
LOCUSID
28964
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 28964
MIM: 608434
HGNC: 4272
Ensembl: ENSG00000108262

Variants:

dbSNP: 28964
ClinVar: 28964
TCGA: ENSG00000108262
COSMIC: GIT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108262ENST00000225394Q9Y2X7
ENSG00000108262ENST00000335356E7EVC2
ENSG00000108262ENST00000394869Q9Y2X7
ENSG00000108262ENST00000577466K7EIX6
ENSG00000108262ENST00000578266J3QL89
ENSG00000108262ENST00000578670J3QQI0
ENSG00000108262ENST00000579937J3QRU8
ENSG00000108262ENST00000581348A0A0C4DGN6
ENSG00000108262ENST00000583413K7EN79
ENSG00000108262ENST00000585148J3QLH1

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Regulation of actin cytoskeletonKEGGhsa04810
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
Ephrin signalingREACTOMER-HSA-3928664

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369946872023Pan-cancer analysis of the oncogenic effects of G-protein-coupled receptor kinase-interacting protein-1 and validation on liver hepatocellular carcinoma.0
369946872023Pan-cancer analysis of the oncogenic effects of G-protein-coupled receptor kinase-interacting protein-1 and validation on liver hepatocellular carcinoma.0
353183022022GIT1 protects against breast cancer growth through negative regulation of Notch.4
353183022022GIT1 protects against breast cancer growth through negative regulation of Notch.4
332583892021GIT1 overexpression promotes epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma.21
337524802021Exosomal miR-122-5p inhibits tumorigenicity of gastric cancer by downregulating GIT1.10
332583892021GIT1 overexpression promotes epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma.21
337524802021Exosomal miR-122-5p inhibits tumorigenicity of gastric cancer by downregulating GIT1.10
304174662019Alternative RNA splicing of the GIT1 gene is associated with neuroendocrine prostate cancer.12
315023022019GIT1 regulates angiogenic factor secretion in bone marrow mesenchymal stem cells via NF-κB/Notch signalling to promote angiogenesis.12
318320022019MicroRNA-760 acts as a tumor suppressor in gastric cancer development via inhibiting G-protein-coupled receptor kinase interacting protein-1 transcription.6
304174662019Alternative RNA splicing of the GIT1 gene is associated with neuroendocrine prostate cancer.12
315023022019GIT1 regulates angiogenic factor secretion in bone marrow mesenchymal stem cells via NF-κB/Notch signalling to promote angiogenesis.12
318320022019MicroRNA-760 acts as a tumor suppressor in gastric cancer development via inhibiting G-protein-coupled receptor kinase interacting protein-1 transcription.6
291919422018β-PIX plays an important role in regulation of intestinal epithelial restitution by interacting with GIT1 and Rac1 after wounding.7

Citation

Dessen P

GIT1 (GIT ArfGAP 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53101/meetings/tumors-explorer/gene-fusions/?id=53101