PRMT7 (protein arginine methyltransferase 7)

2012-12-01  

Identity

HGNC
PRMT7
LOCATION
16q22.1
LOCUSID
54496
ALIAS
SBIDDS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54496
MIM: 610087
HGNC: 25557
Ensembl: ENSG00000132600

Variants:

dbSNP: 54496
ClinVar: 54496
TCGA: ENSG00000132600
COSMIC: PRMT7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132600ENST00000339507Q9NVM4
ENSG00000132600ENST00000339507A0A024R726
ENSG00000132600ENST00000441236Q9NVM4
ENSG00000132600ENST00000441236A0A024R726
ENSG00000132600ENST00000449359Q9NVM4
ENSG00000132600ENST00000562050H3BTY1
ENSG00000132600ENST00000562381H3BRQ9
ENSG00000132600ENST00000565745H3BRD3
ENSG00000132600ENST00000566341H3BTY1
ENSG00000132600ENST00000566657H3BNS2
ENSG00000132600ENST00000568975H3BNC0
ENSG00000132600ENST00000569047H3BSS9
ENSG00000132600ENST00000569571H3BPZ8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
RMTs methylate histone argininesREACTOMER-HSA-3214858

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363480132023Short stature in PRMT7 Mutations: first evidence of response to growth hormone treatment.3
363991342023Biallelic PRMT7 pathogenic variants are associated with a recognizable syndromic neurodevelopmental disorder with short stature, obesity, and craniofacial and digital abnormalities.1
372163642023The exquisite specificity of human protein arginine methyltransferase 7 (PRMT7) toward Arg-X-Arg sites.1
363480132023Short stature in PRMT7 Mutations: first evidence of response to growth hormone treatment.3
363991342023Biallelic PRMT7 pathogenic variants are associated with a recognizable syndromic neurodevelopmental disorder with short stature, obesity, and craniofacial and digital abnormalities.1
372163642023The exquisite specificity of human protein arginine methyltransferase 7 (PRMT7) toward Arg-X-Arg sites.1
352645792022An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression.3
352885572022The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.26
352645792022An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression.3
352885572022The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.26
337824012021Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth.45
340415222021The role of protein arginine methyltransferase 7 in human developmentally arrested embryos cultured in vitro.3
341712972021Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity.26
337824012021Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth.45
340415222021The role of protein arginine methyltransferase 7 in human developmentally arrested embryos cultured in vitro.3

Citation

Dessen P

PRMT7 (protein arginine methyltransferase 7)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53107/teaching-explorer/meetings/teaching-explorer/