EXO5 (exonuclease 5)

2013-01-01 Affiliation

Identity

HGNC

EXO5

LOCATION

1p34.2

LOCUSID

64789

ALIAS

C1orf176,DEM1,Exo

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 64789
MIM: 618601
HGNC: 26115
Ensembl: ENSG00000164002

Variants:

dbSNP: 64789
ClinVar: 64789
TCGA: ENSG00000164002
COSMIC: EXO5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000164002	ENST00000296380	Q9H790
ENSG00000164002	ENST00000358527	Q9H790
ENSG00000164002	ENST00000372703	Q9H790
ENSG00000164002	ENST00000415550	X6RK18
ENSG00000164002	ENST00000418186	X6RCL8
ENSG00000164002	ENST00000419161	X6RCY3
ENSG00000164002	ENST00000420209	X6RF29
ENSG00000164002	ENST00000432259	X6RLK1
ENSG00000164002	ENST00000443729	X6RCY3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
34197737	2021	EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.	21
34197737	2021	EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.	21
31616062	2020	Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis.	8
31616062	2020	Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis.	8
29761480	2018	Whole exome sequencing identifies PLEC, EXO5 and DNAH7 as novel susceptibility genes in testicular cancer.	14
29761480	2018	Whole exome sequencing identifies PLEC, EXO5 and DNAH7 as novel susceptibility genes in testicular cancer.	14
23095756	2012	Human exonuclease 5 is a novel sliding exonuclease required for genome stability.	14
23095756	2012	Human exonuclease 5 is a novel sliding exonuclease required for genome stability.	14

Citation

Dessen P

EXO5 (exonuclease 5)

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/gene/53140/gene-fusions-explorer/teaching-explorer/deep-insight-explorer/