GPR34 (G protein-coupled receptor 34)

2013-02-01  

Identity

HGNC
GPR34
LOCATION
Xp11.4
LOCUSID
2857
ALIAS
LYPSR1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2857
MIM: 300241
HGNC: 4490
Ensembl: ENSG00000171659

Variants:

dbSNP: 2857
ClinVar: 2857
TCGA: ENSG00000171659
COSMIC: GPR34

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171659ENST00000378138Q9UPC5
ENSG00000171659ENST00000378138Q5VT14
ENSG00000171659ENST00000378142Q9UPC5
ENSG00000171659ENST00000378142Q5VT14
ENSG00000171659ENST00000620846Q3SAH0
ENSG00000171659ENST00000649219Q9UPC5
ENSG00000171659ENST00000649219Q5VT14

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383263472024Structural basis for lysophosphatidylserine recognition by GPR34.0
383263472024Structural basis for lysophosphatidylserine recognition by GPR34.0
377337392023Cryo-EM structures of human GPR34 enable the identification of selective antagonists.1
380483602023Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.0
377337392023Cryo-EM structures of human GPR34 enable the identification of selective antagonists.1
380483602023Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.0
340868892022GPR34 activation potentially bridges lymphoepithelial lesions to genesis of salivary gland MALT lymphoma.8
349974282022G-protein coupled receptor 34 regulates the proliferation and growth of LS174T cells through differential expression of PI3K subunits and PTEN.2
357703032022G-protein Coupled Receptor 34 Promotes Gliomagenesis by Inducing Proliferation and Malignant Phenotype via TGF-Beta/Smad Signaling Pathway.0
340868892022GPR34 activation potentially bridges lymphoepithelial lesions to genesis of salivary gland MALT lymphoma.8
349974282022G-protein coupled receptor 34 regulates the proliferation and growth of LS174T cells through differential expression of PI3K subunits and PTEN.2
357703032022G-protein Coupled Receptor 34 Promotes Gliomagenesis by Inducing Proliferation and Malignant Phenotype via TGF-Beta/Smad Signaling Pathway.0
330861482021MicroRNA-381 targets G protein-Coupled receptor 34 (GPR34) to regulate the growth, migration and invasion of human cervical cancer cells.7
330861482021MicroRNA-381 targets G protein-Coupled receptor 34 (GPR34) to regulate the growth, migration and invasion of human cervical cancer cells.7
321245992020Membrane Phospholipid Analogues as Molecular Rulers to Probe the Position of the Hydrophobic Contact Point of Lysophospholipid Ligands on the Surface of G-Protein-Coupled Receptor during Membrane Approach.3

Citation

Dessen P

GPR34 (G protein-coupled receptor 34)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53155/meetings/css/lib/case-report-explorer/