PJA2 (praja ring finger ubiquitin ligase 2)

2013-02-01  

Identity

HGNC
PJA2
LOCATION
5q21.3
LOCUSID
9867
ALIAS
Neurodap1,RNF131
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9867
HGNC: 17481
Ensembl: ENSG00000198961

Variants:

dbSNP: 9867
ClinVar: 9867
TCGA: ENSG00000198961
COSMIC: PJA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198961ENST00000361189O43164
ENSG00000198961ENST00000361557O43164

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383790852024Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer.0
388023402024Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by PJA2.0
383790852024Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer.0
388023402024Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by PJA2.0
334611742021Praja2 suppresses the growth of gastric cancer by ubiquitylation of KSR1 and inhibiting MEK-ERK signal pathways.6
334611742021Praja2 suppresses the growth of gastric cancer by ubiquitylation of KSR1 and inhibiting MEK-ERK signal pathways.6
283456032017PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription.19
283456032017PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription.19
271956772016praja2 regulates KSR1 stability and mitogenic signaling.18
271956772016praja2 regulates KSR1 stability and mitogenic signaling.18
236520102013Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth.64
239318492013Detection of novel paraja ring finger 2-fer tyrosine kinase mRNA chimeras is associated with poor postoperative prognosis in non-small cell lung cancer.8
236520102013Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth.64
239318492013Detection of novel paraja ring finger 2-fer tyrosine kinase mRNA chimeras is associated with poor postoperative prognosis in non-small cell lung cancer.8
229487572012Expression of the ring ligase PRAJA2 in thyroid cancer.15

Citation

Dessen P

PJA2 (praja ring finger ubiquitin ligase 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53166/css/haematological-explorer/