CAND1 (cullin associated and neddylation dissociated 1)

2013-02-01  

Identity

HGNC
CAND1
LOCATION
12q14.3
LOCUSID
55832
ALIAS
TIP120,TIP120A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55832
MIM: 607727
HGNC: 30688
Ensembl: ENSG00000111530

Variants:

dbSNP: 55832
ClinVar: 55832
TCGA: ENSG00000111530
COSMIC: CAND1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111530ENST00000540319H0YH27
ENSG00000111530ENST00000540525F5H6I6
ENSG00000111530ENST00000544619A0A0C4DGH5
ENSG00000111530ENST00000545606Q86VP6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370284292023Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.7
373396242023Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange.3
381481152023ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3.2
370284292023Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.7
373396242023Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange.3
381481152023ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3.2
356617102022Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.2
356617102022Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.2
315115732019CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum.5
315115732019CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum.5
288714252018miR-33a inhibits cell proliferation and invasion by targeting CAND1 in lung cancer.15
288714252018miR-33a inhibits cell proliferation and invasion by targeting CAND1 in lung cancer.15
283880442017Disclosing the Interaction of Carbonic Anhydrase IX with Cullin-Associated NEDD8-Dissociated Protein 1 by Molecular Modeling and Integrated Binding Measurements.10
283880442017Disclosing the Interaction of Carbonic Anhydrase IX with Cullin-Associated NEDD8-Dissociated Protein 1 by Molecular Modeling and Integrated Binding Measurements.10
262199752015CAND1 exchange factor promotes Keap1 integration into cullin 3-RING ubiquitin ligase during adipogenesis.9

Citation

Dessen P

CAND1 (cullin associated and neddylation dissociated 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53172/tumors-explorer/img/cancer-prone-explorer/