FAM3B (FAM3 metabolism regulating signaling molecule B)

2013-02-01  

Identity

HGNC
FAM3B
LOCATION
21q22.3
LOCUSID
54097
ALIAS
2-21,C21orf11,C21orf76,ORF9,PANDER,PRED44
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54097
MIM: 608617
HGNC: 1253
Ensembl: ENSG00000183844

Variants:

dbSNP: 54097
ClinVar: 54097
TCGA: ENSG00000183844
COSMIC: FAM3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183844ENST00000357985P58499
ENSG00000183844ENST00000398646A8MTF8
ENSG00000183844ENST00000398647P58499
ENSG00000183844ENST00000398652P58499

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378476472024Loss of feedback regulation between FAM3B and androgen receptor driving prostate cancer progression.1
378476472024Loss of feedback regulation between FAM3B and androgen receptor driving prostate cancer progression.1
371053872023Identification of rare loss-of-function variants in FAM3B associated with non-syndromic orofacial clefts.0
371053872023Identification of rare loss-of-function variants in FAM3B associated with non-syndromic orofacial clefts.0
324421622020Upregulation of FAM3B Promotes Cisplatin Resistance in Gastric Cancer by Inducing Epithelial-Mesenchymal Transition.5
324421622020Upregulation of FAM3B Promotes Cisplatin Resistance in Gastric Cancer by Inducing Epithelial-Mesenchymal Transition.5
305653872019FAM3B promotes progression of oesophageal carcinoma via regulating the AKT-MDM2-p53 signalling axis and the epithelial-mesenchymal transition.15
309823682019Increased pancreatic-derived factor (PANDER) levels in gestational diabetes mellitus.3
305653872019FAM3B promotes progression of oesophageal carcinoma via regulating the AKT-MDM2-p53 signalling axis and the epithelial-mesenchymal transition.15
309823682019Increased pancreatic-derived factor (PANDER) levels in gestational diabetes mellitus.3
293578402018FAM3B/PANDER inhibits cell death and increases prostate tumor growth by modulating the expression of Bcl-2 and Bcl-X(L) cell survival genes.9
293578402018FAM3B/PANDER inhibits cell death and increases prostate tumor growth by modulating the expression of Bcl-2 and Bcl-X(L) cell survival genes.9
293578402018FAM3B/PANDER inhibits cell death and increases prostate tumor growth by modulating the expression of Bcl-2 and Bcl-X(L) cell survival genes.9
293578402018FAM3B/PANDER inhibits cell death and increases prostate tumor growth by modulating the expression of Bcl-2 and Bcl-X(L) cell survival genes.9
281613822017Association of serum pancreatic derived factor (PANDER) with beta-cell dysfunction in type 2 diabetes mellitus.5

Citation

Dessen P

FAM3B (FAM3 metabolism regulating signaling molecule B)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53174/gene-explorer/case-report-explorer/