ZNF268 (zinc finger protein 268)

2013-03-01 Affiliation

Identity

HGNC

ZNF268

LOCATION

12q24.33

LOCUSID

10795

ALIAS

HZF3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10795
MIM: 604753
HGNC: 13061
Ensembl: ENSG00000090612

Variants:

dbSNP: 10795
ClinVar: 10795
TCGA: ENSG00000090612
COSMIC: ZNF268

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000090612	ENST00000228289	Q14587
ENSG00000090612	ENST00000416488	E7EV44
ENSG00000090612	ENST00000500625	K7EMS6
ENSG00000090612	ENST00000536435	Q14587
ENSG00000090612	ENST00000536899	F5H1T2
ENSG00000090612	ENST00000539248	Q14587
ENSG00000090612	ENST00000541009	A0A075B6T9
ENSG00000090612	ENST00000541211	F5H7L3
ENSG00000090612	ENST00000541975	F5H467
ENSG00000090612	ENST00000542711	F5H670
ENSG00000090612	ENST00000542986	F5H848
ENSG00000090612	ENST00000546126	F5H6R9
ENSG00000090612	ENST00000588312	Q14587
ENSG00000090612	ENST00000591951	K7EIF0
ENSG00000090612	ENST00000592241	K7EQP6
ENSG00000090612	ENST00000611984	A0A087WV54

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
31835635	2019	KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.	6
31835635	2019	KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.	6
23665872	2013	Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.	13
23665872	2013	Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.	13
22235304	2012	Knockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells.	16
23091055	2012	The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling.	21
22235304	2012	Knockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells.	16
23091055	2012	The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling.	21
18375384	2008	Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway.	13
18677094	2008	A splice variant of the C(2)H(2)-type zinc finger protein, ZNF268s, regulates NF-kappaB activation by TNF-alpha.	6
18774934	2008	The mammalian gene ZNF268 is regulated by hUpf1.	0
18949428	2008	Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy.	10
18375384	2008	Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway.	13
18677094	2008	A splice variant of the C(2)H(2)-type zinc finger protein, ZNF268s, regulates NF-kappaB activation by TNF-alpha.	6
18774934	2008	The mammalian gene ZNF268 is regulated by hUpf1.	0

Citation

Dessen P

ZNF268 (zinc finger protein 268)

Atlas Genet Cytogenet Oncol Haematol. 2013-03-01

Online version: http://atlasgeneticsoncology.org/gene/53202/css/lib/case-report-explorer/