RBFOX2 (RNA binding fox-1 homolog 2)

2013-03-01  

Identity

HGNC
RBFOX2
LOCATION
22q12.3
LOCUSID
23543
ALIAS
FOX2,Fox-2,HNRBP2,HRNBP2,RBM9,RTA,dJ106I20.3,fxh
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23543
MIM: 612149
HGNC: 9906
Ensembl: ENSG00000100320

Variants:

dbSNP: 23543
ClinVar: 23543
TCGA: ENSG00000100320
COSMIC: RBFOX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100320ENST00000262829O43251
ENSG00000100320ENST00000359369B0QYY4
ENSG00000100320ENST00000397303B0QYV1
ENSG00000100320ENST00000397305B0QYY6
ENSG00000100320ENST00000405409O43251
ENSG00000100320ENST00000408983B0QYY7
ENSG00000100320ENST00000414461O43251
ENSG00000100320ENST00000416721O43251
ENSG00000100320ENST00000438146O43251
ENSG00000100320ENST00000449924O43251
ENSG00000100320ENST00000473487S4R469
ENSG00000100320ENST00000495377S4R3K7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR2REACTOMER-HSA-5654738
FGFR2 alternative splicingREACTOMER-HSA-6803529

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369492002023RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer.19
372648732023RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in gastric cancer.0
378221602023FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing.4
381144982023RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing.3
369492002023RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer.19
372648732023RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in gastric cancer.0
378221602023FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing.4
381144982023RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing.3
352696582022The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation.2
354041072022Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies.6
364667112022The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the Progression and Prognosis of Esophageal Cancer.0
352696582022The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation.2
354041072022Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies.6
364667112022The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the Progression and Prognosis of Esophageal Cancer.0
340092962021ERG transcription factors have a splicing regulatory function involving RBFOX2 that is altered in the EWS-FLI1 oncogenic fusion.6

Citation

Dessen P

RBFOX2 (RNA binding fox-1 homolog 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-03-01

Online version: http://atlasgeneticsoncology.org/gene/53203/css/js/gene-fusions-explorer/