SNX5 (sorting nexin 5)

2013-05-01  

Identity

HGNC
LOCATION
20p11.23
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 27131
MIM: 605937
HGNC: 14969
Ensembl: ENSG00000089006

Variants:

dbSNP: 27131
ClinVar: 27131
TCGA: ENSG00000089006
COSMIC: SNX5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089006ENST00000377759Q9Y5X3
ENSG00000089006ENST00000377768Q9Y5X3
ENSG00000089006ENST00000419004Q5QPE4
ENSG00000089006ENST00000431277Q5QPE5
ENSG00000089006ENST00000463050A0A087WUY5
ENSG00000089006ENST00000481323U3KQL0
ENSG00000089006ENST00000486039U3KQL0
ENSG00000089006ENST00000606557Q9Y5X3
ENSG00000089006ENST00000606557A0A0S2Z5F1
ENSG00000089006ENST00000606602U3KQP5

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
369775962023The association of lipid transfer protein VPS13A with endosomes is mediated by sorting nexin SNX5.1
369775962023The association of lipid transfer protein VPS13A with endosomes is mediated by sorting nexin SNX5.1
365285562022Overexpression of lncRNA HOXA-AS2 promotes the progression of oral squamous cell carcinoma by mediating SNX5 expression.1
365285562022Overexpression of lncRNA HOXA-AS2 promotes the progression of oral squamous cell carcinoma by mediating SNX5 expression.1
333286392021Sorting nexin 5 mediates virus-induced autophagy and immunity.40
333286392021Sorting nexin 5 mediates virus-induced autophagy and immunity.40
318063682020SNX5 inhibits RLR-mediated antiviral signaling by targeting RIG-I-VISA signalosome.3
318191692020Upregulation of SNX5 predicts poor prognosis and promotes hepatocellular carcinoma progression by modulating the EGFR-ERK1/2 signaling pathway.27
318063682020SNX5 inhibits RLR-mediated antiviral signaling by targeting RIG-I-VISA signalosome.3
318191692020Upregulation of SNX5 predicts poor prognosis and promotes hepatocellular carcinoma progression by modulating the EGFR-ERK1/2 signaling pathway.27
315760582019Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins.56
315760582019Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins.56
294449452018Interaction of Human Cytomegalovirus Tegument Proteins ppUL35 and ppUL35A with Sorting Nexin 5 Regulates Glycoprotein B (gpUL55) Localization.14
297433632018Comparative Characterization of the Sindbis Virus Proteome from Mammalian and Invertebrate Hosts Identifies nsP2 as a Component of the Virion and Sorting Nexin 5 as a Significant Host Factor for Alphavirus Replication.14
304190032018The phosphorylation of sorting nexin 5 at serine 226 regulates retrograde transport and macropinocytosis.10

Citation

Dessen P

SNX5 (sorting nexin 5)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53258/deep-insight-explorer/js/lib/case-report-explorer/