MMP7 (matrix metallopeptidase 7)

2013-06-01  

Identity

HGNC
MMP7
LOCATION
11q22.2
LOCUSID
4316
ALIAS
MMP-7,MPSL1,PUMP-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4316
MIM: 178990
HGNC: 7174
Ensembl: ENSG00000137673

Variants:

dbSNP: 4316
ClinVar: 4316
TCGA: ENSG00000137673
COSMIC: MMP7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137673ENST00000260227P09237

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Assembly of collagen fibrils and other multimeric structuresREACTOMER-HSA-2022090
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389
Collagen degradationREACTOMER-HSA-1442490

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366452032024MAGP1 maintains tumorigenicity and angiogenesis of laryngeal cancer by activating Wnt/β-catenin/MMP7 pathway.4
379028722024The magnetic resonance imaging and age-adjusted matrix metalloproteinase-7 assist the diagnosis of biliary atresia.1
380730392024Matrix Metalloproteinase-7 in Urinary Extracellular Vesicles Identifies Rapid Disease Progression in Autosomal Dominant Polycystic Kidney Disease.0
384852502024Utility of peripheral protein biomarkers for the prediction of incident interstitial features: a multicentre retrospective cohort study.0
385225062024Neurotensin contributes to cholestatic liver disease potentially modulating matrix metalloprotease-7.0
389149922024Relationships of serum MMP-7 and clinical characteristics in choledochal cyst children.0
389258472024Contribution of Matrix Metalloproteinase-7 Genotypes to Endometriosis Risk in Taiwan.0
366452032024MAGP1 maintains tumorigenicity and angiogenesis of laryngeal cancer by activating Wnt/β-catenin/MMP7 pathway.4
379028722024The magnetic resonance imaging and age-adjusted matrix metalloproteinase-7 assist the diagnosis of biliary atresia.1
380730392024Matrix Metalloproteinase-7 in Urinary Extracellular Vesicles Identifies Rapid Disease Progression in Autosomal Dominant Polycystic Kidney Disease.0
384852502024Utility of peripheral protein biomarkers for the prediction of incident interstitial features: a multicentre retrospective cohort study.0
385225062024Neurotensin contributes to cholestatic liver disease potentially modulating matrix metalloprotease-7.0
389149922024Relationships of serum MMP-7 and clinical characteristics in choledochal cyst children.0
389258472024Contribution of Matrix Metalloproteinase-7 Genotypes to Endometriosis Risk in Taiwan.0
360666682023Matrix metalloproteinase 7 is associated with clinical and pathological characteristics of salivary adenoid cystic carcinomas.0

Citation

Dessen P

MMP7 (matrix metallopeptidase 7)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53331/cancer-prone-explorer/js/favicon/gene-fusions-explorer/