GABARAPL2 (GABA type A receptor associated protein like 2)

2013-07-01  

Identity

HGNC
GABARAPL2
LOCATION
16q23.1
LOCUSID
11345
ALIAS
ATG8,ATG8C,GATE-16,GATE16,GEF-2,GEF2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11345
MIM: 607452
HGNC: 13291
Ensembl: ENSG00000034713

Variants:

dbSNP: 11345
ClinVar: 11345
TCGA: ENSG00000034713
COSMIC: GABARAPL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000034713ENST00000037243P60520
ENSG00000034713ENST00000563744H3BU36
ENSG00000034713ENST00000565057H3BSM5
ENSG00000034713ENST00000568455H3BQ50

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
FoxO signaling pathwayKEGGhsa04068
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
TBC/RABGAPsREACTOMER-HSA-8854214
Apelin signaling pathwayKEGGhsa04371
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373124062024ATG8 proteins are co-factors for human dopaminergic neuronal transcriptional control: implications for neuronal resilience in Parkinson disease.1
373124062024ATG8 proteins are co-factors for human dopaminergic neuronal transcriptional control: implications for neuronal resilience in Parkinson disease.1
349291652022An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins.3
352583972022The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment.1
349291652022An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins.3
352583972022The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment.1
338450852021Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity.10
339099892021Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.65
338450852021Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity.10
339099892021Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.65
309903542020An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5.23
319605292020Curvature-sensitive trans-assembly of human Atg8-family proteins in autophagy-related membrane tethering.10
320942512020GABARAPL2 Is Critical for Growth Restriction of Toxoplasma gondii in HeLa Cells Treated with Gamma Interferon.11
324374992020A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy.46
326854422020Autophagic Network Analysis of the Dual Effect of Sevoflurane on Neurons Associated with GABARAPL1 and 2.3

Citation

Dessen P

GABARAPL2 (GABA type A receptor associated protein like 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53460/css/lib/gene-fusions-explorer/js/case-report-explorer/