CHST15 (carbohydrate sulfotransferase 15)

2013-08-01  

Identity

HGNC
CHST15
LOCATION
10q26.13
LOCUSID
51363
ALIAS
BRAG,GALNAC4S-6ST
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51363
MIM: 608277
HGNC: 18137
Ensembl: ENSG00000182022

Variants:

dbSNP: 51363
ClinVar: 51363
TCGA: ENSG00000182022
COSMIC: CHST15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182022ENST00000346248Q7LFX5
ENSG00000182022ENST00000435907Q7LFX5
ENSG00000182022ENST00000462406A0A0D9SFZ3
ENSG00000182022ENST00000628426Q7LFX5

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfateKEGGko00532
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfateKEGGhsa00532
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Chondroitin sulfate/dermatan sulfate metabolismREACTOMER-HSA-1793185
Chondroitin sulfate biosynthesisREACTOMER-HSA-2022870

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
366080572023Association of genetic variants of CircCHST15 with oral squamous cell carcinoma in the Chinese Han population.0
366080572023Association of genetic variants of CircCHST15 with oral squamous cell carcinoma in the Chinese Han population.0
357987032022CHST15 gene germline mutation is associated with the development of familial myeloproliferative neoplasms and higher transformation risk.5
357987032022CHST15 gene germline mutation is associated with the development of familial myeloproliferative neoplasms and higher transformation risk.5
349225392021circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis.19
349225392021circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis.19
317464002020CHST15 promotes the proliferation of TE‑1 cells via multiple pathways in esophageal cancer.8
317464002020CHST15 promotes the proliferation of TE‑1 cells via multiple pathways in esophageal cancer.8
309635682019Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15.25
309635682019Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15.25
274106852016Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis.24
274106852016Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis.24
266423492015Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model.15
266423492015Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model.15
233498462013Role of GalNAc4S-6ST in astrocytic tumor progression.10

Citation

Dessen P

CHST15 (carbohydrate sulfotransferase 15)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53475/favicon/js/case-report-explorer/